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Research Article

Biochemical Properties of Highly Neuroinvasive Prion Strains

  • Cyrus Bett,

    Affiliation: Departments of Pathology and Medicine, University of California, San Diego, La Jolla, California, United States of America

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  • Shivanjali Joshi-Barr,

    Affiliation: Departments of Pathology and Medicine, University of California, San Diego, La Jolla, California, United States of America

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  • Melanie Lucero,

    Affiliation: Departments of Pathology and Medicine, University of California, San Diego, La Jolla, California, United States of America

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  • Margarita Trejo,

    Affiliation: Department of Neuroscience, University of California, San Diego, La Jolla, California, United States of America

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  • Pawel Liberski,

    Affiliation: Department of Molecular Pathology and Neuropathology, Medical University, Lodz, Poland

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  • Jeffery W. Kelly,

    Affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America

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  • Eliezer Masliah,

    Affiliation: Department of Neuroscience, University of California, San Diego, La Jolla, California, United States of America

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  • Christina J. Sigurdson mail

    csigurdson@ucsd.edu

    Affiliations: Departments of Pathology and Medicine, University of California, San Diego, La Jolla, California, United States of America, Department of Pathology, Microbiology, and Immunology, University of California, Davis, California, United States of America

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  • Published: February 02, 2012
  • DOI: 10.1371/journal.ppat.1002522

About the Authors

Cyrus Bett, Shivanjali Joshi-Barr, Melanie Lucero, Christina J. Sigurdson
Departments of Pathology and Medicine, University of California, San Diego, La Jolla, California, United States of America
Margarita Trejo, Eliezer Masliah
Department of Neuroscience, University of California, San Diego, La Jolla, California, United States of America
Pawel Liberski
Department of Molecular Pathology and Neuropathology, Medical University, Lodz, Poland
Jeffery W. Kelly
Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America
Christina J. Sigurdson
Department of Pathology, Microbiology, and Immunology, University of California, Davis, California, United States of America

Corresponding Author

Email: csigurdson@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CB CJS. Performed the experiments: CB SJB ML MT PL CJS. Analyzed the data: CB SJB MT EM JWK PL CJS. Wrote the paper: CB CJS.