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Research Article

Introgression of Ivermectin Resistance Genes into a Susceptible Haemonchus contortus Strain by Multiple Backcrossing

  • Elizabeth Redman equal contributor,

    equal contributor Contributed equally to this work with: Elizabeth Redman, Neil Sargison

    Affiliation: Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Neil Sargison equal contributor,

    equal contributor Contributed equally to this work with: Elizabeth Redman, Neil Sargison

    Affiliation: Moredun Research Institute, Pentlands Science Park, Midlothian, United Kingdom

    Current address: Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom

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  • Fiona Whitelaw,

    Affiliation: Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Frank Jackson,

    Affiliation: Moredun Research Institute, Pentlands Science Park, Midlothian, United Kingdom

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  • Alison Morrison,

    Affiliation: Moredun Research Institute, Pentlands Science Park, Midlothian, United Kingdom

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  • David Jon Bartley,

    Affiliation: Moredun Research Institute, Pentlands Science Park, Midlothian, United Kingdom

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  • John Stuart Gilleard mail

    jsgillea@ucalgary.ca

    Affiliation: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

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  • Published: February 16, 2012
  • DOI: 10.1371/journal.ppat.1002534

About the Authors

Elizabeth Redman, Fiona Whitelaw
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Neil Sargison, Frank Jackson, Alison Morrison, David Jon Bartley
Moredun Research Institute, Pentlands Science Park, Midlothian, United Kingdom
John Stuart Gilleard
Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

Corresponding Author

Email: jsgillea@ucalgary.ca

Competing Interests

I have read the journal's policy and have the following conflicts. The study received some funding support from Pfizer Animal Health PLC. This does not alter our adherence to all the PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JSG NS ER. Performed the experiments: NS ER FJ AAM DJB FW. Analyzed the data: NS ER DJB. Wrote the paper: NS ER JSG. Backcrossing and animal work: NS ER FJ AAM DJB. Genotyping: ER NS FW. Supervision and critical reading of the manuscript: JSG DJB.