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Research Article

Plasmacytoid Dendritic Cells Sequester High Prion Titres at Early Stages of Prion Infection

  • Rocio Castro-Seoane,

    Affiliation: MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

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  • Holger Hummerich,

    Affiliation: MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

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  • Trevor Sweeting,

    Affiliation: Department of Statistical Science, University College London, London, United Kingdom

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  • M. Howard Tattum,

    Affiliation: MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

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  • Jacqueline M. Linehan,

    Affiliation: MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

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  • Mar Fernandez de Marco,

    Affiliation: MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

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  • Sebastian Brandner,

    Affiliation: MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

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  • John Collinge,

    Affiliation: MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

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  • Peter-Christian Klöhn mail

    p.kloehn@prion.ucl.ac.uk

    Affiliation: MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom

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  • Published: February 16, 2012
  • DOI: 10.1371/journal.ppat.1002538

About the Authors

Rocio Castro-Seoane, Holger Hummerich, M. Howard Tattum, Jacqueline M. Linehan, Mar Fernandez de Marco, Sebastian Brandner, John Collinge, Peter-Christian Klöhn
MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom
Trevor Sweeting
Department of Statistical Science, University College London, London, United Kingdom

Corresponding Author

Email: p.kloehn@prion.ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RCS PCK. Performed the experiments: RCS MHT MF. Analyzed the data: RCS HH TS JML MF SB PCK. Contributed reagents/materials/analysis tools: TS. Wrote the paper: PCK TS JC.