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Research Article

Transient Reversal of Episome Silencing Precedes VP16-Dependent Transcription during Reactivation of Latent HSV-1 in Neurons

  • Ju Youn Kim,

    Affiliation: Department of Microbiology, New York University School of Medicine, New York, New York, United States of America

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  • Angelo Mandarino,

    Affiliations: Department of Microbiology, New York University School of Medicine, New York, New York, United States of America, Via Manzoni, Viagrande, Italy

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  • Moses V. Chao,

    Affiliation: Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine and Departments of Cell Biology, Physiology and Neuroscience, Psychiatry and Center for Neural Science, New York University School of Medicine, New York, New York, United States of America

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  • Ian Mohr,

    Affiliation: Department of Microbiology, New York University School of Medicine, New York, New York, United States of America

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  • Angus C. Wilson mail

    angus.wilson@med.nyu.edu

    Affiliation: Department of Microbiology, New York University School of Medicine, New York, New York, United States of America

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  • Published: February 23, 2012
  • DOI: 10.1371/journal.ppat.1002540

About the Authors

Ju Youn Kim, Angelo Mandarino, Ian Mohr, Angus C. Wilson
Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
Angelo Mandarino
Via Manzoni, Viagrande, Italy
Moses V. Chao
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine and Departments of Cell Biology, Physiology and Neuroscience, Psychiatry and Center for Neural Science, New York University School of Medicine, New York, New York, United States of America

Corresponding Author

Email: angus.wilson@med.nyu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JYK AM MVC IM ACW. Performed the experiments: JYK AM. Analyzed the data: JYK AM MVC IM ACW. Contributed reagents/materials/analysis tools: MVC IM ACW. Wrote the paper: JYK MVC IM ACW.