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Research Article

Nonequivalence of Classical MHC Class I Loci in Ability to Direct Effective Antiviral Immunity

  • Kevin D. Pavelko equal contributor,

    equal contributor Contributed equally to this work with: Kevin D. Pavelko, Yanice Mendez-Fernandez

    Affiliation: Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Yanice Mendez-Fernandez equal contributor,

    equal contributor Contributed equally to this work with: Kevin D. Pavelko, Yanice Mendez-Fernandez

    Affiliation: Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America

    Current address: Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Michael P. Bell,

    Affiliation: Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Michael J. Hansen,

    Affiliation: Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Aaron J. Johnson,

    Affiliations: Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Chella S. David,

    Affiliation: Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Moses Rodriguez,

    Affiliations: Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Larry R. Pease mail

    pease.larry@mayo.edu

    Affiliation: Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Published: February 23, 2012
  • DOI: 10.1371/journal.ppat.1002541

About the Authors

Kevin D. Pavelko, Yanice Mendez-Fernandez, Michael P. Bell, Michael J. Hansen, Aaron J. Johnson, Chella S. David, Moses Rodriguez, Larry R. Pease
Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America
Aaron J. Johnson, Moses Rodriguez
Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

Corresponding Author

Email: pease.larry@mayo.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KDP YM-F AJJ LRP. Performed the experiments: KDP YM-F MPB MJH. Analyzed the data: KDP YM-F MR LRP. Contributed reagents/materials/analysis tools: AJJ CSD MR LRP. Wrote the paper: KDP YM-F MR LRP. Generated transgenic mice: CSD.