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Research Article

PK-sensitive PrPSc Is Infectious and Shares Basic Structural Features with PK-resistant PrPSc

  • Gustavo Sajnani mail,

    gsajnani@sescam.jccm.es

    Affiliation: Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galiza, Spain

    Current address: Neural Repair and Biomaterials Lab, National Paraplegia Hospital, Toledo, Spain

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  • Christopher J. Silva,

    Affiliation: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America

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  • Adriana Ramos,

    Affiliation: Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galiza, Spain

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  • Miguel A. Pastrana,

    Affiliation: Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galiza, Spain

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  • Bruce C. Onisko,

    Affiliation: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America

    Current address: OniPro, Kensington, California, United States of America

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  • Melissa L. Erickson,

    Affiliation: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America

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  • Elizabeth M. Antaki,

    Affiliations: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America, Department of Pathology, University of California, Davis, Davis, California, United States of America

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  • Irina Dynin,

    Affiliation: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America

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  • Ester Vázquez-Fernández,

    Affiliation: Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galiza, Spain

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  • Christina J. Sigurdson,

    Affiliations: Department of Pathology, University of California, Davis, Davis, California, United States of America, Department of Pathology, University of California, San Diego, La Jolla, California, United States of America

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  • J. Mark Carter,

    Affiliation: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America

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  • Jesús R. Requena

    Affiliation: Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galiza, Spain

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.ppat.1002547

About the Authors

Gustavo Sajnani, Adriana Ramos, Miguel A. Pastrana, Ester Vázquez-Fernández, Jesús R. Requena
Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galiza, Spain
Christopher J. Silva, Bruce C. Onisko, Melissa L. Erickson, Elizabeth M. Antaki, Irina Dynin, J. Mark Carter
Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America
Elizabeth M. Antaki, Christina J. Sigurdson
Department of Pathology, University of California, Davis, Davis, California, United States of America
Christina J. Sigurdson
Department of Pathology, University of California, San Diego, La Jolla, California, United States of America

Corresponding Author

Email: gsajnani@sescam.jccm.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GS CJS MAP BCO CJS JMC JRR. Performed the experiments: GS CJS AR MLE EMA ID EVF. Analyzed the data: GS CJS BCO CJS EVF JRR. Wrote the paper: GS CJS JRR.