Advertisement
Research Article

A P-loop Mutation in Gα Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis

  • Dustin E. Bosch equal contributor,

    equal contributor Contributed equally to this work with: Dustin E. Bosch, Francis S. Willard

    Affiliation: Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Francis S. Willard equal contributor mail,

    equal contributor Contributed equally to this work with: Dustin E. Bosch, Francis S. Willard

    willardfs@lilly.com (FSW); dsiderov@med.unc.edu (DPS)

    Affiliation: Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    Current address: Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America

    X
  • Ravikrishna Ramanujam,

    Affiliations: Fungal Patho-Biology Group, Temasek Life Sciences Laboratory, Singapore, School of Biological Sciences, Nanyang Technological University, Singapore

    X
  • Adam J. Kimple,

    Affiliation: Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Melinda D. Willard,

    Affiliation: Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    Current address: Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America

    X
  • Naweed I. Naqvi,

    Affiliations: Fungal Patho-Biology Group, Temasek Life Sciences Laboratory, Singapore, School of Biological Sciences, Nanyang Technological University, Singapore, Department of Biological Sciences, National University of Singapore, Singapore

    X
  • David P. Siderovski mail

    willardfs@lilly.com (FSW); dsiderov@med.unc.edu (DPS)

    Affiliations: Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, UNC Neuroscience Center and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Published: February 23, 2012
  • DOI: 10.1371/journal.ppat.1002553

About the Authors

Dustin E. Bosch, Francis S. Willard, Adam J. Kimple, Melinda D. Willard, David P. Siderovski
Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Ravikrishna Ramanujam, Naweed I. Naqvi
Fungal Patho-Biology Group, Temasek Life Sciences Laboratory, Singapore
Ravikrishna Ramanujam, Naweed I. Naqvi
School of Biological Sciences, Nanyang Technological University, Singapore
Naweed I. Naqvi
Department of Biological Sciences, National University of Singapore, Singapore
David P. Siderovski
UNC Neuroscience Center and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DEB FSW RR AJK MDW NIN DPS. Performed the experiments: DEB FSW RR AJK MDW. Analyzed the data: DEB FSW RR NIN DPS. Contributed reagents/materials/analysis tools: DPS NIN. Wrote the paper: DEB FSW NIN DPS.