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Research Article

Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox

  • Melanie Kremer equal contributor,

    equal contributor Contributed equally to this work with: Melanie Kremer, Yasemin Suezer, Asisa Volz

    Affiliation: Institute for Infectious Diseases and Zoonoses, University of Munich LMU, Muenchen, Germany

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  • Yasemin Suezer equal contributor,

    equal contributor Contributed equally to this work with: Melanie Kremer, Yasemin Suezer, Asisa Volz

    Affiliation: Paul-Ehrlich-Institut, Langen, Germany

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  • Asisa Volz equal contributor,

    equal contributor Contributed equally to this work with: Melanie Kremer, Yasemin Suezer, Asisa Volz

    Affiliation: Institute for Infectious Diseases and Zoonoses, University of Munich LMU, Muenchen, Germany

    X
  • Theresa Frenz,

    Affiliation: Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and Hannover Medical School, Hannover, Germany

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  • Monir Majzoub,

    Affiliation: Institute of Veterinary Pathology, University of Munich LMU, Muenchen, Germany

    X
  • Kay-Martin Hanschmann,

    Affiliation: Paul-Ehrlich-Institut, Langen, Germany

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  • Michael H. Lehmann,

    Affiliation: Institute for Infectious Diseases and Zoonoses, University of Munich LMU, Muenchen, Germany

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  • Ulrich Kalinke,

    Affiliation: Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and Hannover Medical School, Hannover, Germany

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  • Gerd Sutter mail

    gerd.sutter@lmu.de

    Affiliation: Institute for Infectious Diseases and Zoonoses, University of Munich LMU, Muenchen, Germany

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.ppat.1002557

About the Authors

Melanie Kremer, Asisa Volz, Michael H. Lehmann, Gerd Sutter
Institute for Infectious Diseases and Zoonoses, University of Munich LMU, Muenchen, Germany
Yasemin Suezer, Kay-Martin Hanschmann
Paul-Ehrlich-Institut, Langen, Germany
Theresa Frenz, Ulrich Kalinke
Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and Hannover Medical School, Hannover, Germany
Monir Majzoub
Institute of Veterinary Pathology, University of Munich LMU, Muenchen, Germany

Corresponding Author

Email: gerd.sutter@lmu.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MK YS AV MHL TF UK GS. Performed the experiments: MK YS AV TF MM MHL. Analyzed the data: MK YS AV TF MM KMH MHL UK GS. Contributed reagents/materials/analysis tools: KMH MM MHL UK GS. Wrote the paper: MK YS AV MHL UK GS.