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Research Article

LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

  • Rik Schrijvers,

    Affiliation: Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium

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  • Jan De Rijck,

    Affiliation: Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium

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  • Jonas Demeulemeester,

    Affiliation: Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium

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  • Noritaka Adachi,

    Affiliation: Graduate School of Nanobioscience, Yokohama City University, Yokohama, Japan

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  • Sofie Vets,

    Affiliation: Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium

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  • Keshet Ronen,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Frauke Christ,

    Affiliation: Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium

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  • Frederic D. Bushman,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Zeger Debyser mail,

    rik.gijsbers@med.kuleuven.be (RG); zeger.debyser@med.kuleuven.be (ZD)

    Affiliation: Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium

    These authors are joint senior authors on this work.

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  • Rik Gijsbers mail

    rik.gijsbers@med.kuleuven.be (RG); zeger.debyser@med.kuleuven.be (ZD)

    Affiliation: Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium

    These authors are joint senior authors on this work.

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.ppat.1002558

About the Authors

Rik Schrijvers, Jan De Rijck, Jonas Demeulemeester, Sofie Vets, Frauke Christ, Zeger Debyser, Rik Gijsbers
Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium
Noritaka Adachi
Graduate School of Nanobioscience, Yokohama City University, Yokohama, Japan
Keshet Ronen, Frederic D. Bushman
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RS JDR NA RG ZD. Performed the experiments: RS JD NA. Analyzed the data: RS JDR JD NA FC RG ZD. Contributed reagents/materials/analysis tools: KR FDB SV. Wrote the paper: RS JDR RG ZD.