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Research Article

Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA

  • Kouyuki Hirayasu equal contributor mail,

    equal contributor Contributed equally to this work with: Kouyuki Hirayasu, Toshio Yabe

    hirayasu@ifrec.osaka-u.ac.jp (KH); to-yabe@tokyo.bc.jrc.or.jp (TY)

    Affiliations: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Japan Society for the Promotion of Science, Tokyo, Japan, Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan, Department of Immunochemistry, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Jun Ohashi,

    Affiliation: Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

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  • Koichi Kashiwase,

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Hathairad Hananantachai,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Izumi Naka,

    Affiliation: Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

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  • Atsuko Ogawa,

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Minoko Takanashi,

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Masahiro Satake,

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Kazunori Nakajima,

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Peter Parham,

    Affiliation: Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, California, United States of America

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  • Hisashi Arase,

    Affiliations: Department of Immunochemistry, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

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  • Katsushi Tokunaga,

    Affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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  • Jintana Patarapotikul,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Toshio Yabe equal contributor mail

    equal contributor Contributed equally to this work with: Kouyuki Hirayasu, Toshio Yabe

    hirayasu@ifrec.osaka-u.ac.jp (KH); to-yabe@tokyo.bc.jrc.or.jp (TY)

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Published: March 08, 2012
  • DOI: 10.1371/journal.ppat.1002565

About the Authors

Kouyuki Hirayasu, Katsushi Tokunaga
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Kouyuki Hirayasu
Japan Society for the Promotion of Science, Tokyo, Japan
Kouyuki Hirayasu, Koichi Kashiwase, Atsuko Ogawa, Minoko Takanashi, Masahiro Satake, Kazunori Nakajima, Toshio Yabe
Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan
Kouyuki Hirayasu, Hisashi Arase
Department of Immunochemistry, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
Jun Ohashi, Izumi Naka
Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
Hathairad Hananantachai, Jintana Patarapotikul
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Peter Parham
Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, California, United States of America
Hisashi Arase
Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
Hisashi Arase
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KH JO PP HA KT JP TY. Performed the experiments: KH JO HH IN JP. Analyzed the data: KH JO PP TY. Contributed reagents/materials/analysis tools: KK AO MT MS KN. Wrote the paper: KH JO PP HA TY.