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Research Article

E2F1 Mediated Apoptosis Induced by the DNA Damage Response Is Blocked by EBV Nuclear Antigen 3C in Lymphoblastoid Cells

  • Abhik Saha,

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Jie Lu,

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Lise Morizur,

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Santosh K. Upadhyay,

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Mahadesh Prasad AJ,

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Erle S. Robertson mail

    erle@mail.med.upenn.edu

    Affiliation: Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.ppat.1002573

About the Authors

Abhik Saha, Jie Lu, Lise Morizur, Santosh K. Upadhyay, Mahadesh Prasad AJ, Erle S. Robertson
Department of Microbiology and Tumor Virology Program of the Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: erle@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS ESR. Performed the experiments: AS LM MPAJ. Analyzed the data: AS ESR. Contributed reagents/materials/analysis tools: JL LM SKU MPAJ. Wrote the paper: AS ESR.