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Research Article

Calcium Influx Rescues Adenylate Cyclase-Hemolysin from Rapid Cell Membrane Removal and Enables Phagocyte Permeabilization by Toxin Pores

  • Radovan Fiser equal contributor,

    equal contributor Contributed equally to this work with: Radovan Fiser, Jiri Masin

    Affiliations: Faculty of Science, Charles University, Prague, Czech Republic, Institute of Microbiology of the ASCR, v.v.i., Prague, Czech Republic

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  • Jiri Masin equal contributor,

    equal contributor Contributed equally to this work with: Radovan Fiser, Jiri Masin

    Affiliation: Institute of Microbiology of the ASCR, v.v.i., Prague, Czech Republic

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  • Ladislav Bumba,

    Affiliation: Institute of Microbiology of the ASCR, v.v.i., Prague, Czech Republic

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  • Eva Pospisilova,

    Affiliation: Institute of Microbiology of the ASCR, v.v.i., Prague, Czech Republic

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  • Catherine Fayolle,

    Affiliations: Institut Pasteur, Paris, France, INSERM U1041, Paris, France

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  • Marek Basler,

    Affiliation: Institute of Microbiology of the ASCR, v.v.i., Prague, Czech Republic

    Current address: Harvard Medical School, Boston, Massachusetts, United States of America

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  • Lenka Sadilkova,

    Affiliation: Institute of Microbiology of the ASCR, v.v.i., Prague, Czech Republic

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  • Irena Adkins,

    Affiliation: Institute of Microbiology of the ASCR, v.v.i., Prague, Czech Republic

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  • Jana Kamanova,

    Affiliation: Institute of Microbiology of the ASCR, v.v.i., Prague, Czech Republic

    Current address: Yale Medical School, New Haven, Connecticut, United States of America

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  • Jan Cerny,

    Affiliation: Faculty of Science, Charles University, Prague, Czech Republic

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  • Ivo Konopasek,

    Affiliation: Faculty of Science, Charles University, Prague, Czech Republic

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  • Radim Osicka,

    Affiliation: Institute of Microbiology of the ASCR, v.v.i., Prague, Czech Republic

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  • Claude Leclerc,

    Affiliations: Institut Pasteur, Paris, France, INSERM U1041, Paris, France

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  • Peter Sebo mail

    sebo@biomed.cas.cz

    Affiliations: Institute of Microbiology of the ASCR, v.v.i., Prague, Czech Republic, Institute of Biotechnology of the ASCR, v.v.i., Prague, Czech Republic

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  • Published: April 05, 2012
  • DOI: 10.1371/journal.ppat.1002580

About the Authors

Radovan Fiser, Jan Cerny, Ivo Konopasek
Faculty of Science, Charles University, Prague, Czech Republic
Radovan Fiser, Jiri Masin, Ladislav Bumba, Eva Pospisilova, Marek Basler, Lenka Sadilkova, Irena Adkins, Jana Kamanova, Radim Osicka, Peter Sebo
Institute of Microbiology of the ASCR, v.v.i., Prague, Czech Republic
Catherine Fayolle, Claude Leclerc
Institut Pasteur, Paris, France
Catherine Fayolle, Claude Leclerc
INSERM U1041, Paris, France
Peter Sebo
Institute of Biotechnology of the ASCR, v.v.i., Prague, Czech Republic

Corresponding Author

Email: sebo@biomed.cas.cz

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RF JM LB JK JC RO CL PS. Performed the experiments: RF JM LB EP CF MB LS IA JK. Analyzed the data: RF JM JC IK RO CL PS. Wrote the paper: RF JM RO CL PS.