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Research Article

Mannose Binding Lectin Is Required for Alphavirus-Induced Arthritis/Myositis

  • Bronwyn M. Gunn equal contributor,

    equal contributor Contributed equally to this work with: Bronwyn M. Gunn, Thomas E. Morrison

    Affiliations: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Carolina Vaccine Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Thomas E. Morrison equal contributor,

    equal contributor Contributed equally to this work with: Bronwyn M. Gunn, Thomas E. Morrison

    Affiliation: Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America

    X
  • Alan C. Whitmore,

    Affiliation: Carolina Vaccine Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Lance K. Blevins,

    Affiliation: Carolina Vaccine Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Linda Hueston,

    Affiliation: Arbovirus Emerging Disease Unit, CIDMLS-ICPMR, Westmead Hospital, Westmead, Australia

    X
  • Robert J. Fraser,

    Affiliation: Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia

    X
  • Lara J. Herrero,

    Affiliations: Virus and Inflammation Research Group, University of Canberra, Canberra, Australia, Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Australia

    X
  • Ruben Ramirez,

    Affiliation: Virus and Inflammation Research Group, University of Canberra, Canberra, Australia

    X
  • Paul N. Smith,

    Affiliation: The Australian National University, Canberra, Australia

    X
  • Suresh Mahalingam mail,

    s.mahalingam@griffith.edu.au (SM); heisem@med.unc.edu (MTH)

    Affiliations: Virus and Inflammation Research Group, University of Canberra, Canberra, Australia, Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Australia

    X
  • Mark T. Heise mail

    s.mahalingam@griffith.edu.au (SM); heisem@med.unc.edu (MTH)

    Affiliations: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Carolina Vaccine Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: March 22, 2012
  • DOI: 10.1371/journal.ppat.1002586

About the Authors

Bronwyn M. Gunn, Mark T. Heise
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Bronwyn M. Gunn, Alan C. Whitmore, Lance K. Blevins, Mark T. Heise
Carolina Vaccine Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Thomas E. Morrison
Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America
Linda Hueston
Arbovirus Emerging Disease Unit, CIDMLS-ICPMR, Westmead Hospital, Westmead, Australia
Robert J. Fraser
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
Lara J. Herrero, Ruben Ramirez, Suresh Mahalingam
Virus and Inflammation Research Group, University of Canberra, Canberra, Australia
Lara J. Herrero, Suresh Mahalingam
Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Australia
Paul N. Smith
The Australian National University, Canberra, Australia
Mark T. Heise
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BMG TEM SM MTH. Performed the experiments: BMG TEM ACW LKB LJH RR PNS. Analyzed the data: BMG TEM LJH SM MTH. Contributed reagents/materials/analysis tools: LH RJF. Wrote the paper: BMG MTH.