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Research Article

Inflammation and Disintegration of Intestinal Villi in an Experimental Model for Vibrio parahaemolyticus-Induced Diarrhea

  • Jennifer M. Ritchie mail,

    mwaldor@rics.bwh.harvard.edu (MKW); jennymritchie@gmail.com (JMR)

    Affiliation: Brigham and Women's Hospital/Harvard Medical School and HHMI, Boston, Massachusetts, United States of America

    Current address: Faculty of Health & Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom

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  • Haopeng Rui,

    Affiliation: Brigham and Women's Hospital/Harvard Medical School and HHMI, Boston, Massachusetts, United States of America

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  • Xiaohui Zhou,

    Affiliation: Brigham and Women's Hospital/Harvard Medical School and HHMI, Boston, Massachusetts, United States of America

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  • Tetsuya Iida,

    Affiliation: Department of Bacterial Infections, International Research Center for Infectious Diseases, Osaka University, Suita, Osaka, Japan

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  • Toshio Kodoma,

    Affiliation: Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Osaka University, Suita, Osaka, Japan

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  • Susuma Ito,

    Affiliation: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Brigid M. Davis,

    Affiliation: Brigham and Women's Hospital/Harvard Medical School and HHMI, Boston, Massachusetts, United States of America

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  • Roderick T. Bronson,

    Affiliation: Department of Microbiology & Immunology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Matthew K. Waldor mail

    mwaldor@rics.bwh.harvard.edu (MKW); jennymritchie@gmail.com (JMR)

    Affiliation: Brigham and Women's Hospital/Harvard Medical School and HHMI, Boston, Massachusetts, United States of America

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.ppat.1002593

About the Authors

Jennifer M. Ritchie, Haopeng Rui, Xiaohui Zhou, Brigid M. Davis, Matthew K. Waldor
Brigham and Women's Hospital/Harvard Medical School and HHMI, Boston, Massachusetts, United States of America
Tetsuya Iida
Department of Bacterial Infections, International Research Center for Infectious Diseases, Osaka University, Suita, Osaka, Japan
Toshio Kodoma
Laboratory of Genomic Research on Pathogenic Bacteria, International Research Center for Infectious Diseases, Osaka University, Suita, Osaka, Japan
Susuma Ito
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America
Roderick T. Bronson
Department of Microbiology & Immunology, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMR HR MKW. Performed the experiments: JMR HR XZ. Analyzed the data: JMR HR SI RTB. Contributed reagents/materials/analysis tools: TI TK SI RTB. Wrote the paper: JMR BMD MKW.