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Research Article

Direct Recognition of Fusobacterium nucleatum by the NK Cell Natural Cytotoxicity Receptor NKp46 Aggravates Periodontal Disease

  • Stella Chaushu equal contributor,

    equal contributor Contributed equally to this work with: Stella Chaushu, Asaf Wilensky, Chamutal Gur

    Affiliation: Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel

    X
  • Asaf Wilensky equal contributor,

    equal contributor Contributed equally to this work with: Stella Chaushu, Asaf Wilensky, Chamutal Gur

    Affiliation: Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel

    X
  • Chamutal Gur equal contributor,

    equal contributor Contributed equally to this work with: Stella Chaushu, Asaf Wilensky, Chamutal Gur

    Affiliation: Lautenberg Center of General and Tumor Immunology, Hebrew University –Hadassah School of Medicine, IMRIC, Jerusalem, Israel

    X
  • Lior Shapira,

    Affiliation: Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel

    X
  • Moran Elboim,

    Affiliation: Lautenberg Center of General and Tumor Immunology, Hebrew University –Hadassah School of Medicine, IMRIC, Jerusalem, Israel

    X
  • Gili Halftek,

    Affiliation: Lautenberg Center of General and Tumor Immunology, Hebrew University –Hadassah School of Medicine, IMRIC, Jerusalem, Israel

    X
  • David Polak,

    Affiliation: Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel

    X
  • Hagit Achdout,

    Affiliation: Lautenberg Center of General and Tumor Immunology, Hebrew University –Hadassah School of Medicine, IMRIC, Jerusalem, Israel

    X
  • Gilad Bachrach,

    Affiliation: Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel

    These authors also contributed equally to this work.

    X
  • Ofer Mandelboim mail

    oferm@ekmd.huji.ac.il

    Affiliation: Lautenberg Center of General and Tumor Immunology, Hebrew University –Hadassah School of Medicine, IMRIC, Jerusalem, Israel

    X
  • Published: March 22, 2012
  • DOI: 10.1371/journal.ppat.1002601

About the Authors

Stella Chaushu, Asaf Wilensky, Lior Shapira, David Polak, Gilad Bachrach
Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel
Chamutal Gur, Moran Elboim, Gili Halftek, Hagit Achdout, Ofer Mandelboim
Lautenberg Center of General and Tumor Immunology, Hebrew University –Hadassah School of Medicine, IMRIC, Jerusalem, Israel

Corresponding Author

Email: oferm@ekmd.huji.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SC AW. Performed the experiments: SC AW. Analyzed the data: OM GB. Contributed reagents/materials/analysis tools: SC AW LS ME GH DP CG HA. Wrote the paper: SC AW OM GB.