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Research Article

Thriving under Stress: Selective Translation of HIV-1 Structural Protein mRNA during Vpr-Mediated Impairment of eIF4E Translation Activity

  • Amit Sharma,

    Affiliations: Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, United States of America, Center for Retrovirus Research, Ohio State University, Columbus, Ohio, United States of America, Center for RNA Biology, Ohio State University, Columbus, Ohio, United States of America, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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  • Alper Yilmaz,

    Affiliations: Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, United States of America, Center for Retrovirus Research, Ohio State University, Columbus, Ohio, United States of America, Center for RNA Biology, Ohio State University, Columbus, Ohio, United States of America, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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  • Kim Marsh,

    Affiliation: Department of Molecular Genetics, University of Toronto, Toronto, Canada

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  • Alan Cochrane,

    Affiliation: Department of Molecular Genetics, University of Toronto, Toronto, Canada

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  • Kathleen Boris-Lawrie mail

    boris-lawrie.1@osu.edu

    Affiliations: Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, United States of America, Center for Retrovirus Research, Ohio State University, Columbus, Ohio, United States of America, Center for RNA Biology, Ohio State University, Columbus, Ohio, United States of America, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

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  • Published: March 22, 2012
  • DOI: 10.1371/journal.ppat.1002612

About the Authors

Amit Sharma, Alper Yilmaz, Kathleen Boris-Lawrie
Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio, United States of America
Amit Sharma, Alper Yilmaz, Kathleen Boris-Lawrie
Center for Retrovirus Research, Ohio State University, Columbus, Ohio, United States of America
Amit Sharma, Alper Yilmaz, Kathleen Boris-Lawrie
Center for RNA Biology, Ohio State University, Columbus, Ohio, United States of America
Amit Sharma, Alper Yilmaz, Kathleen Boris-Lawrie
Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America
Kim Marsh, Alan Cochrane
Department of Molecular Genetics, University of Toronto, Toronto, Canada

Corresponding Author

Email: boris-lawrie.1@osu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KBL AC AS AY. Performed the experiments: AS AY KM. Analyzed the data: KBL AC AS AY KM. Wrote the paper: KBL AC AS.