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Research Article

Productive Hepatitis C Virus Infection of Stem Cell-Derived Hepatocytes Reveals a Critical Transition to Viral Permissiveness during Differentiation

  • Xianfang Wu,

    Affiliation: Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America

    X
  • Jason M. Robotham,

    Affiliation: Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America

    X
  • Emily Lee,

    Affiliation: Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America

    X
  • Stephen Dalton,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America

    X
  • Norman M. Kneteman,

    Affiliation: Division of Transplantation, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada

    X
  • David M. Gilbert,

    Affiliation: Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America

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  • Hengli Tang mail

    tang@bio.fsu.edu

    Affiliation: Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America

    X
  • Published: April 05, 2012
  • DOI: 10.1371/journal.ppat.1002617

About the Authors

Xianfang Wu, Jason M. Robotham, Emily Lee, David M. Gilbert, Hengli Tang
Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
Stephen Dalton
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America
Norman M. Kneteman
Division of Transplantation, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada

Corresponding Author

Email: tang@bio.fsu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XW HT. Performed the experiments: XW JMR EL. Analyzed the data: XW JMR EL HT. Contributed reagents/materials/analysis tools: DMG SD NMK. Wrote the paper: HT.