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Research Article

Group A Streptococcus Secreted Esterase Hydrolyzes Platelet-Activating Factor to Impede Neutrophil Recruitment and Facilitate Innate Immune Evasion

  • Mengyao Liu equal contributor,

    equal contributor Contributed equally to this work with: Mengyao Liu, Hui Zhu

    Affiliation: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

    X
  • Hui Zhu equal contributor,

    equal contributor Contributed equally to this work with: Mengyao Liu, Hui Zhu

    Affiliations: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America, Department of Physiology, Harbin Medical University, Harbin, People's Republic of China

    X
  • Jinquan Li,

    Affiliations: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, People's Republic of China

    X
  • Cristiana C. Garcia,

    Affiliation: Laboratory of Immunopharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Wenchao Feng,

    Affiliation: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

    X
  • Liliya N. Kirpotina,

    Affiliation: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

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  • Jonathan Hilmer,

    Affiliation: Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana, United States of America

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  • Luciana P. Tavares,

    Affiliation: Laboratory of Immunopharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    X
  • Arthur W. Layton,

    Affiliation: Montana Veterinary Diagnostic Laboratory, Bozeman, Montana, United States of America

    X
  • Mark T. Quinn,

    Affiliation: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

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  • Brian Bothner,

    Affiliation: Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana, United States of America

    X
  • Mauro M. Teixeira,

    Affiliation: Laboratory of Immunopharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil

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  • Benfang Lei mail

    blei@montana.edu

    Affiliation: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America

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  • Published: April 05, 2012
  • DOI: 10.1371/journal.ppat.1002624

About the Authors

Mengyao Liu, Hui Zhu, Jinquan Li, Wenchao Feng, Liliya N. Kirpotina, Mark T. Quinn, Benfang Lei
Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, United States of America
Hui Zhu
Department of Physiology, Harbin Medical University, Harbin, People's Republic of China
Jinquan Li
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, People's Republic of China
Cristiana C. Garcia, Luciana P. Tavares, Mauro M. Teixeira
Laboratory of Immunopharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil
Jonathan Hilmer, Brian Bothner
Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana, United States of America
Arthur W. Layton
Montana Veterinary Diagnostic Laboratory, Bozeman, Montana, United States of America

Corresponding Author

Email: blei@montana.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ML HZ BL. Performed the experiments: ML HZ JL CCG WF LNK JH LPT BL. Analyzed the data: ML HZ CCG LNK JH AWL MTQ MMT BL. Contributed reagents/materials/analysis tools: BB. Wrote the paper: ML HZ BL.