Advertisement
Research Article

β-Microseminoprotein Endows Post Coital Seminal Plasma with Potent Candidacidal Activity by a Calcium- and pH-Dependent Mechanism

  • Anneli M. L. Edström Hägerwall,

    Affiliation: Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

    X
  • Victoria Rydengård,

    Affiliation: Division of Dermatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

    X
  • Per Fernlund,

    Affiliation: Division of Clinical Chemistry, Department of Laboratory Medicine Malmö, Lund University, Malmö, Sweden

    X
  • Matthias Mörgelin,

    Affiliation: Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

    X
  • Maria Baumgarten,

    Affiliation: Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

    X
  • Alexander M. Cole,

    Affiliation: Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America

    X
  • Martin Malmsten,

    Affiliation: Department of Pharmacy, Uppsala University, Uppsala, Sweden

    X
  • Birthe B. Kragelund,

    Affiliation: Structural Biology and NMR Laboratory, Department of Biology, University of Copenhagen, Copenhagen, Denmark

    X
  • Ole E. Sørensen mail

    Ole_E.Sorensen@med.lu.se

    Affiliation: Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

    X
  • Published: April 05, 2012
  • DOI: 10.1371/journal.ppat.1002625

About the Authors

Anneli M. L. Edström Hägerwall, Matthias Mörgelin, Maria Baumgarten, Ole E. Sørensen
Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
Victoria Rydengård
Division of Dermatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
Per Fernlund
Division of Clinical Chemistry, Department of Laboratory Medicine Malmö, Lund University, Malmö, Sweden
Alexander M. Cole
Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America
Martin Malmsten
Department of Pharmacy, Uppsala University, Uppsala, Sweden
Birthe B. Kragelund
Structural Biology and NMR Laboratory, Department of Biology, University of Copenhagen, Copenhagen, Denmark

Corresponding Author

Email: Ole_E.Sorensen@med.lu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: OES AMLEH AMC. Performed the experiments: VR MM MB PF AMLEH BBK MM. Analyzed the data: MM OES AMLEH BBK AMC. Contributed reagents/materials/analysis tools: MM PF BBK. Wrote the paper: OES AMLEH BBK AMC.