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Research Article

The Transcription Factor AmrZ Utilizes Multiple DNA Binding Modes to Recognize Activator and Repressor Sequences of Pseudomonas aeruginosa Virulence Genes

  • Edward E. Pryor Jr.,

    Affiliation: Department of Biochemistry and Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Elizabeth A. Waligora,

    Affiliation: Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Binjie Xu,

    Affiliation: Departments of Microbiology and Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio, United States of America

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  • Sheri Dellos-Nolan,

    Affiliation: Departments of Microbiology and Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio, United States of America

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  • Daniel J. Wozniak,

    Affiliations: Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, Departments of Microbiology and Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio, United States of America

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  • Thomas Hollis mail

    thollis@wakehealth.edu

    Affiliation: Department of Biochemistry and Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Published: April 12, 2012
  • DOI: 10.1371/journal.ppat.1002648

About the Authors

Edward E. Pryor Jr., Thomas Hollis
Department of Biochemistry and Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Elizabeth A. Waligora, Daniel J. Wozniak
Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
Binjie Xu, Sheri Dellos-Nolan, Daniel J. Wozniak
Departments of Microbiology and Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio, United States of America

Corresponding Author

Email: thollis@wakehealth.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EEP DJW TH. Performed the experiments: EEP EAW BX SDN. Analyzed the data: EEP EAW BX SDN DJW TH. Contributed reagents/materials/analysis tools: EEP EAW BX SDN DJW TH. Wrote the paper: EEP TH.