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Research Article

In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells

  • Scott G. Kitchen mail,

    skitchen@ucla.edu

    Affiliation: Division of Hematology-Oncology, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Bernard R. Levin,

    Affiliation: Division of Hematology-Oncology, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Gregory Bristol,

    Affiliation: Division of Hematology-Oncology, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Valerie Rezek,

    Affiliation: Division of Hematology-Oncology, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Sohn Kim,

    Affiliation: Division of Hematology-Oncology, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Christian Aguilera-Sandoval,

    Affiliations: Department of Microbiology, Immunology, and Molecular Genetics, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, The UCLA AIDS Institute, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Arumugam Balamurugan,

    Affiliation: Division of Infectious Diseases, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Otto O. Yang,

    Affiliations: Department of Microbiology, Immunology, and Molecular Genetics, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, The UCLA AIDS Institute, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, Division of Infectious Diseases, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Jerome A. Zack

    Affiliations: Division of Hematology-Oncology, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, Department of Microbiology, Immunology, and Molecular Genetics, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, The UCLA AIDS Institute, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Published: April 12, 2012
  • DOI: 10.1371/journal.ppat.1002649

About the Authors

Scott G. Kitchen, Bernard R. Levin, Gregory Bristol, Valerie Rezek, Sohn Kim, Jerome A. Zack
Division of Hematology-Oncology, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
Christian Aguilera-Sandoval, Otto O. Yang, Jerome A. Zack
Department of Microbiology, Immunology, and Molecular Genetics, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
Christian Aguilera-Sandoval, Otto O. Yang, Jerome A. Zack
The UCLA AIDS Institute, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
Arumugam Balamurugan, Otto O. Yang
Division of Infectious Diseases, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

Corresponding Author

Email: skitchen@ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SGK JAZ. Performed the experiments: SGK BRL GB VR CAS AB SK. Analyzed the data: SGK BRL. Contributed reagents/materials/analysis tools: SGK GB JAZ OOY. Wrote the paper: SGK. Designed quantitative PCR for plasma viral RNA: GB.