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Research Article

Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate

  • Zhen-yong Keck,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Jinming Xia,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Yong Wang,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Wenyan Wang,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Thomas Krey,

    Affiliation: Institut Pasteur, CNRS URA3015, Unite de Virologie Structurale, Paris, France

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  • Jannick Prentoe,

    Affiliations: Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Thomas Carlsen,

    Affiliations: Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Angela Ying-Jian Li,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Arvind H. Patel,

    Affiliation: MRC – University of Glasgow Centre for Virus Research, Glasgow, United Kingdom

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  • Stanley M. Lemon,

    Affiliation: Lineberger Comprehensive Cancer Center and the Division of Infectious Diseases, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Jens Bukh,

    Affiliations: Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Felix A. Rey,

    Affiliation: Institut Pasteur, CNRS URA3015, Unite de Virologie Structurale, Paris, France

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  • Steven K. H. Foung mail

    sfoung@stanford.edu

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: April 12, 2012
  • DOI: 10.1371/journal.ppat.1002653

About the Authors

Zhen-yong Keck, Jinming Xia, Yong Wang, Wenyan Wang, Angela Ying-Jian Li, Steven K. H. Foung
Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
Thomas Krey, Felix A. Rey
Institut Pasteur, CNRS URA3015, Unite de Virologie Structurale, Paris, France
Jannick Prentoe, Thomas Carlsen, Jens Bukh
Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark
Jannick Prentoe, Thomas Carlsen, Jens Bukh
Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Arvind H. Patel
MRC – University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
Stanley M. Lemon
Lineberger Comprehensive Cancer Center and the Division of Infectious Diseases, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: sfoung@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZYK SKHF. Performed the experiments: JX YW WW TC JP AL. Analyzed the data: ZYK JP TC TK JB FAR SKHF. Contributed reagents/materials/analysis tools: AHP SML. Wrote the paper: ZYK SKHF.