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Research Article

CLEC5A Regulates Japanese Encephalitis Virus-Induced Neuroinflammation and Lethality

  • Szu-Ting Chen,

    Affiliations: Department and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan, Genomics Research Center, Academia Sinica, Taipei, Taiwan

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  • Ren-Shyan Liu,

    Affiliation: Molecular and Genetic Imaging Core, Department of Nuclear Medicine, National Yang-Ming University Medical School and Taipei Veterans General Hospital, Taipei, Taiwan

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  • Ming-Fang Wu,

    Affiliation: Department and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan

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  • Yi-Ling Lin,

    Affiliations: Genomics Research Center, Academia Sinica, Taipei, Taiwan, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

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  • Se-Yi Chen,

    Affiliations: Department of Neurosurgery Surgical, Taichung Veterans General Hospital, Taichung, Taiwan, Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

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  • David Tat-Wei Tan,

    Affiliation: Molecular and Genetic Imaging Core, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan

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  • Teh-Ying Chou,

    Affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

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  • I-Shuen Tsai,

    Affiliation: Department and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan

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  • Lei Li,

    Affiliation: Taipei Blood Center, Taiwan Blood Services Foundation, Taipei, Taiwan

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  • Shie-Liang Hsieh mail

    slhsieh@ym.edu.tw

    Affiliations: Department and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan, Genomics Research Center, Academia Sinica, Taipei, Taiwan, Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, Infection and Immunity Research Center, National Yang-Ming University, Taipei, Taiwan, Immunology Center, Taipei Veterans General Hospital, Taipei, Taiwan

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  • Published: April 19, 2012
  • DOI: 10.1371/journal.ppat.1002655

About the Authors

Szu-Ting Chen, Ming-Fang Wu, I-Shuen Tsai, Shie-Liang Hsieh
Department and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan
Szu-Ting Chen, Yi-Ling Lin, Shie-Liang Hsieh
Genomics Research Center, Academia Sinica, Taipei, Taiwan
Ren-Shyan Liu
Molecular and Genetic Imaging Core, Department of Nuclear Medicine, National Yang-Ming University Medical School and Taipei Veterans General Hospital, Taipei, Taiwan
Yi-Ling Lin
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Se-Yi Chen
Department of Neurosurgery Surgical, Taichung Veterans General Hospital, Taichung, Taiwan
Se-Yi Chen, Teh-Ying Chou, Shie-Liang Hsieh
Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
David Tat-Wei Tan
Molecular and Genetic Imaging Core, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan
Lei Li
Taipei Blood Center, Taiwan Blood Services Foundation, Taipei, Taiwan
Shie-Liang Hsieh
Infection and Immunity Research Center, National Yang-Ming University, Taipei, Taiwan
Shie-Liang Hsieh
Immunology Center, Taipei Veterans General Hospital, Taipei, Taiwan

Corresponding Author

Email: slhsieh@ym.edu.tw

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: S-LH S-TC. Performed the experiments: S-TC M-FW DT-WT I-ST. Analyzed the data: S-LH S-TC R-SL S-YC T-YC. Contributed reagents/materials/analysis tools: R-SL Y-LL LL. Wrote the paper: S-TC S-LH.