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Research Article

T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice

  • Daniel R. Neill,

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

    Current address: Department of Clinical Infection, Microbiology & Immunology, Institute of Infection & Global Health, University of Liverpool, Liverpool, United Kingdom.

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  • Vitor E. Fernandes,

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

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  • Laura Wisby,

    Affiliation: MRC Harwell, Mammalian Genetics Unit, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom

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  • Andrew R. Haynes,

    Affiliation: MRC Harwell, Mammalian Genetics Unit, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom

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  • Daniela M. Ferreira,

    Affiliations: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom

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  • Ameera Laher,

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

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  • Natalie Strickland,

    Affiliation: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom

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  • Stephen B. Gordon,

    Affiliation: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom

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  • Paul Denny,

    Affiliation: MRC Harwell, Mammalian Genetics Unit, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom

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  • Aras Kadioglu mail,

    A.Kadioglu@liv.ac.uk (AK); pwa@le.ac.uk (PWA)

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

    Current address: Department of Clinical Infection, Microbiology & Immunology, Institute of Infection & Global Health, University of Liverpool, Liverpool, United Kingdom.

    These authors are joint senior authors on this work.

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  • Peter W. Andrew mail

    A.Kadioglu@liv.ac.uk (AK); pwa@le.ac.uk (PWA)

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

    These authors are joint senior authors on this work.

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  • Published: April 19, 2012
  • DOI: 10.1371/journal.ppat.1002660

About the Authors

Daniel R. Neill, Vitor E. Fernandes, Daniela M. Ferreira, Ameera Laher, Aras Kadioglu, Peter W. Andrew
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
Laura Wisby, Andrew R. Haynes, Paul Denny
MRC Harwell, Mammalian Genetics Unit, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom
Daniela M. Ferreira, Natalie Strickland, Stephen B. Gordon
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DRN AK PD LW PWA. Performed the experiments: DRN VEF LW AH DMF NS AL AK. Analyzed the data: DRN VEF LW AH PD AK PWA. Contributed reagents/materials/analysis tools: SBG AK PWA. Wrote the paper: DRN AK PWA.