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Research Article

A Novel Small Molecule Inhibitor of Influenza A Viruses that Targets Polymerase Function and Indirectly Induces Interferon

  • Mila Brum Ortigoza,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Oliver Dibben,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Jad Maamary,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Luis Martinez-Gil,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Victor H. Leyva-Grado,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Pablo Abreu Jr.,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Juan Ayllon,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Peter Palese,

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Megan L. Shaw mail

    megan.shaw@mssm.edu

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Published: April 26, 2012
  • DOI: 10.1371/journal.ppat.1002668

About the Authors

Mila Brum Ortigoza, Oliver Dibben, Jad Maamary, Luis Martinez-Gil, Victor H. Leyva-Grado, Pablo Abreu Jr., Juan Ayllon, Peter Palese, Megan L. Shaw
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
Peter Palese
Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

Corresponding Author

Email: megan.shaw@mssm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MBO PP MLS. Performed the experiments: MBO OD JM LMG VHLG PA JA. Analyzed the data: MBO PP MLS. Contributed reagents/materials/analysis tools: MBO OD JM LMG VHLG JA PP MLS. Wrote the paper: MBO MLS.