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Research Article

The Lipopolysaccharide Core of Brucella abortus Acts as a Shield Against Innate Immunity Recognition

  • Raquel Conde-Álvarez equal contributor,

    equal contributor Contributed equally to this work with: Raquel Conde-Álvarez, Vilma Arce-Gorvel, Ignacio Moriyón, Jean-Pierre Gorvel

    Affiliations: Institute for Tropical Health and Departamento de Microbiología y Parasitología, Universidad de Navarra, Pamplona, Spain, Focal Area Infection Biology, Biozentrum of the University of Basel, Basel, Switzerland

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  • Vilma Arce-Gorvel equal contributor,

    equal contributor Contributed equally to this work with: Raquel Conde-Álvarez, Vilma Arce-Gorvel, Ignacio Moriyón, Jean-Pierre Gorvel

    Affiliation: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University UM2 Marseille France, Institut National de la Santé et de la Recherche Médicale (INSERM) U1104 Marseille France, Centre National de la Recherche Scientifique (CNRS) UMR7280 Marseille France

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  • Maite Iriarte,

    Affiliation: Institute for Tropical Health and Departamento de Microbiología y Parasitología, Universidad de Navarra, Pamplona, Spain

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  • Mateja Manček-Keber,

    Affiliation: Department of Biotechnology, National Institute of Chemistry, Hajdrihova, Ljubljana, Slovenia

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  • Elías Barquero-Calvo,

    Affiliation: Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica

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  • Leyre Palacios-Chaves,

    Affiliation: Institute for Tropical Health and Departamento de Microbiología y Parasitología, Universidad de Navarra, Pamplona, Spain

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  • Carlos Chacón-Díaz,

    Affiliation: Centro de Investigación en Enfermedades Tropicales, Universidad de Costa Rica, San José, Costa Rica

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  • Esteban Chaves-Olarte,

    Affiliations: Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica, Centro de Investigación en Enfermedades Tropicales, Universidad de Costa Rica, San José, Costa Rica

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  • Anna Martirosyan,

    Affiliation: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University UM2 Marseille France, Institut National de la Santé et de la Recherche Médicale (INSERM) U1104 Marseille France, Centre National de la Recherche Scientifique (CNRS) UMR7280 Marseille France

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  • Kristine von Bargen,

    Affiliation: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University UM2 Marseille France, Institut National de la Santé et de la Recherche Médicale (INSERM) U1104 Marseille France, Centre National de la Recherche Scientifique (CNRS) UMR7280 Marseille France

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  • María-Jesús Grilló,

    Affiliation: Instituto de Agrobiotecnología CSIC-UPNA-Gobierno de Navarra, Pamplona, Spain

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  • Roman Jerala,

    Affiliation: Department of Biotechnology, National Institute of Chemistry, Hajdrihova, Ljubljana, Slovenia

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  • Klaus Brandenburg,

    Affiliation: Forschungzentrum Borstel, Borstel, Germany

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  • Enrique Llobet,

    Affiliation: Laboratory Microbial Patogénesis, Fundación Investigación Sanitaria Illes Balears-CSIC, Bunyola, Spain

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  • José A. Bengoechea,

    Affiliation: Laboratory Microbial Patogénesis, Fundación Investigación Sanitaria Illes Balears-CSIC, Bunyola, Spain

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  • Edgardo Moreno,

    Affiliations: Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica, Instituto Clodomiro Picado, Universidad de Costa Rica, San José, Costa Rica

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  • Ignacio Moriyón equal contributor,

    equal contributor Contributed equally to this work with: Raquel Conde-Álvarez, Vilma Arce-Gorvel, Ignacio Moriyón, Jean-Pierre Gorvel

    Affiliation: Institute for Tropical Health and Departamento de Microbiología y Parasitología, Universidad de Navarra, Pamplona, Spain

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  • Jean-Pierre Gorvel equal contributor mail

    equal contributor Contributed equally to this work with: Raquel Conde-Álvarez, Vilma Arce-Gorvel, Ignacio Moriyón, Jean-Pierre Gorvel

    gorvel@ciml.univ-mrs.fr

    Affiliation: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University UM2 Marseille France, Institut National de la Santé et de la Recherche Médicale (INSERM) U1104 Marseille France, Centre National de la Recherche Scientifique (CNRS) UMR7280 Marseille France

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  • Published: May 10, 2012
  • DOI: 10.1371/journal.ppat.1002675

About the Authors

Raquel Conde-Álvarez, Maite Iriarte, Leyre Palacios-Chaves, Ignacio Moriyón
Institute for Tropical Health and Departamento de Microbiología y Parasitología, Universidad de Navarra, Pamplona, Spain
Raquel Conde-Álvarez
Focal Area Infection Biology, Biozentrum of the University of Basel, Basel, Switzerland
Vilma Arce-Gorvel, Anna Martirosyan, Kristine von Bargen, Jean-Pierre Gorvel
Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University UM2 Marseille France, Institut National de la Santé et de la Recherche Médicale (INSERM) U1104 Marseille France, Centre National de la Recherche Scientifique (CNRS) UMR7280 Marseille France
Mateja Manček-Keber, Roman Jerala
Department of Biotechnology, National Institute of Chemistry, Hajdrihova, Ljubljana, Slovenia
Elías Barquero-Calvo, Esteban Chaves-Olarte, Edgardo Moreno
Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica
Carlos Chacón-Díaz, Esteban Chaves-Olarte
Centro de Investigación en Enfermedades Tropicales, Universidad de Costa Rica, San José, Costa Rica
María-Jesús Grilló
Instituto de Agrobiotecnología CSIC-UPNA-Gobierno de Navarra, Pamplona, Spain
Klaus Brandenburg
Forschungzentrum Borstel, Borstel, Germany
Enrique Llobet, José A. Bengoechea
Laboratory Microbial Patogénesis, Fundación Investigación Sanitaria Illes Balears-CSIC, Bunyola, Spain
Edgardo Moreno
Instituto Clodomiro Picado, Universidad de Costa Rica, San José, Costa Rica

Corresponding Author

Email: gorvel@ciml.univ-mrs.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JPG IM EM RJ JAB MI. Performed the experiments: RCA VAG EBC LPC CCD ECO AM MJG KB EL KVB MMK. Analyzed the data: RCA VAG EBC LPC CCD ECO AM MJG KB EL JPG IM EM RJ JAB MI KVB MMK. Contributed reagents/materials/analysis tools: RCA VAG EBC LPC AM MJG KB EL. Wrote the paper: JPG IM.