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Research Article

Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis

  • Karen K. Y. Lam,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

    Current address: NCE CECR PROOF Centre of Excellence, Vancouver, British Columbia, Canada

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  • Xingji Zheng,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Roberto Forestieri,

    Affiliation: Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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  • Aruna D. Balgi,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Matt Nodwell,

    Affiliation: Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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  • Sarah Vollett,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Hilary J. Anderson,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Raymond J. Andersen,

    Affiliation: Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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  • Yossef Av-Gay,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Michel Roberge mail

    michelr@mail.ubc.ca

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Published: May 10, 2012
  • DOI: 10.1371/journal.ppat.1002691

About the Authors

Karen K. Y. Lam, Aruna D. Balgi, Sarah Vollett, Hilary J. Anderson, Michel Roberge
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
Xingji Zheng, Yossef Av-Gay
Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Roberto Forestieri, Matt Nodwell, Raymond J. Andersen
Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada

Corresponding Author

Email: michelr@mail.ubc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KKYL XZ RF RJA YA MR. Performed the experiments: KKYL XZ RF ADB SV MN. Analyzed the data: KKYL XZ RF HJA RJA YA MR. Contributed reagents/materials/analysis tools: KKYL XZ RF RJA YA MR. Wrote the paper: KKYL HJA RJA YA MR.