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Research Article

ATG5 Is Essential for ATG8-Dependent Autophagy and Mitochondrial Homeostasis in Leishmania major

  • Roderick A. M. Williams,

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Terry K. Smith,

    Affiliation: Schools of Biology & Chemistry, The University of St. Andrews, St. Andrews, United Kingdom

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  • Benjamin Cull,

    Affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Jeremy C. Mottram,

    Affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Graham H. Coombs mail

    graham.coombs@strath.ac.uk

    Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

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  • Published: May 17, 2012
  • DOI: 10.1371/journal.ppat.1002695

About the Authors

Roderick A. M. Williams, Graham H. Coombs
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
Terry K. Smith
Schools of Biology & Chemistry, The University of St. Andrews, St. Andrews, United Kingdom
Benjamin Cull, Jeremy C. Mottram
Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

Corresponding Author

Email: graham.coombs@strath.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RAMW TKS JCM GHC. Performed the experiments: RAMW TKS BC. Analyzed the data: RAMW TKS BC JCM GHC. Contributed reagents/materials/analysis tools: RAMW JCM GHC. Wrote the paper: RAMW TKS JCM GHC.