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Research Article

Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon

  • Seong Gyu Jeon equal contributor,

    equal contributor Contributed equally to this work with: Seong Gyu Jeon, Hisako Kayama

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

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  • Hisako Kayama equal contributor,

    equal contributor Contributed equally to this work with: Seong Gyu Jeon, Hisako Kayama

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

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  • Yoshiyasu Ueda,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

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  • Takuya Takahashi,

    Affiliation: Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan

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  • Takashi Asahara,

    Affiliation: Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan

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  • Hirokazu Tsuji,

    Affiliation: Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan

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  • Noriko M. Tsuji,

    Affiliation: Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

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  • Hiroshi Kiyono,

    Affiliations: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan, Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Ji Su Ma,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

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  • Takashi Kusu,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

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  • Ryu Okumura,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

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  • Hiromitsu Hara,

    Affiliation: Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan

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  • Hiroki Yoshida,

    Affiliation: Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan

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  • Masahiro Yamamoto,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

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  • Koji Nomoto,

    Affiliation: Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan

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  • Kiyoshi Takeda mail

    ktakeda@ongene.med.osaka-u.ac.jp

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

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  • Published: May 31, 2012
  • DOI: 10.1371/journal.ppat.1002714
  • Featured in PLOS Collections

About the Authors

Seong Gyu Jeon, Hisako Kayama, Yoshiyasu Ueda, Ji Su Ma, Takashi Kusu, Ryu Okumura, Masahiro Yamamoto, Kiyoshi Takeda
Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Seong Gyu Jeon, Hisako Kayama, Yoshiyasu Ueda, Ji Su Ma, Takashi Kusu, Ryu Okumura, Masahiro Yamamoto, Kiyoshi Takeda
WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
Seong Gyu Jeon, Hisako Kayama, Yoshiyasu Ueda, Hiroshi Kiyono, Ji Su Ma, Takashi Kusu, Ryu Okumura, Masahiro Yamamoto, Kiyoshi Takeda
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan
Takuya Takahashi, Takashi Asahara, Hirokazu Tsuji, Koji Nomoto
Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
Noriko M. Tsuji
Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan
Hiroshi Kiyono
Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Hiromitsu Hara, Hiroki Yoshida
Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan

Corresponding Author

Email: ktakeda@ongene.med.osaka-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K. Takeda. Performed the experiments: S.G. Jeon, H. Kayama, Y. Ueda, J.S. Ma, T. Kusu, R. Okumura. Analyzed the data: S.G. Jeon, H. Kayama, M. Yamamoto, K. Takeda. Contributed reagents/materials/analysis tools: T. Takahashi, T. Asahara, H. Tsuji, N.M. Tsuji, H. Kiyono, H. Hara, H. Yoshida, K. Nomoto. Wrote the paper: K. Takeda.