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Research Article

Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape

  • Katharine J. Bar,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Chun-yen Tsao,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

    X
  • Shilpa S. Iyer,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Julie M. Decker,

    Affiliation: University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Yongping Yang,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Mattia Bonsignori,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

    X
  • Xi Chen,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

    X
  • Kwan-Ki Hwang,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

    X
  • David C. Montefiori,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

    X
  • Hua-Xin Liao,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

    X
  • Peter Hraber,

    Affiliation: Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • William Fischer,

    Affiliation: Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Hui Li,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Shuyi Wang,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Sarah Sterrett,

    Affiliation: University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Brandon F. Keele,

    Affiliation: SAIC-Frederick Inc, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • Vitaly V. Ganusov,

    Affiliation: University of Tennessee, Knoxville, Tennessee, United States of America

    X
  • Alan S. Perelson,

    Affiliation: Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Bette T. Korber,

    Affiliation: Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Ivelin Georgiev,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Jason S. McLellan,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Jeffrey W. Pavlicek,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

    X
  • Feng Gao,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

    X
  • Barton F. Haynes,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

    X
  • Beatrice H. Hahn,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Peter D. Kwong,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • George M. Shaw mail

    shawg@upenn.edu

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Published: May 31, 2012
  • DOI: 10.1371/journal.ppat.1002721

About the Authors

Katharine J. Bar, Shilpa S. Iyer, Hui Li, Shuyi Wang, Beatrice H. Hahn, George M. Shaw
Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Chun-yen Tsao, Mattia Bonsignori, Xi Chen, Kwan-Ki Hwang, David C. Montefiori, Hua-Xin Liao, Jeffrey W. Pavlicek, Feng Gao, Barton F. Haynes
Duke University School of Medicine, Durham, North Carolina, United States of America
Julie M. Decker, Sarah Sterrett
University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Yongping Yang, Ivelin Georgiev, Jason S. McLellan, Peter D. Kwong
Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
Peter Hraber, William Fischer, Alan S. Perelson, Bette T. Korber
Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America
Brandon F. Keele
SAIC-Frederick Inc, National Cancer Institute, Frederick, Maryland, United States of America
Vitaly V. Ganusov
University of Tennessee, Knoxville, Tennessee, United States of America

Corresponding Author

Email: shawg@upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KJB CT MB WF VVG ASP BTK JSM PDK GMS. Performed the experiments: KJB CT SSI JMD YY MB XC KH HXL HL PH WF SW SS VVG JWP. Analyzed the data: KJB DCM HXL HL BFK VVG ASP BTK IG JSM FG BFH BHH PDK GMS. Wrote the paper: KJB VVG ASP BTK IG BFH BHH PDK GMS.