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Research Article

Shedding of TRAP by a Rhomboid Protease from the Malaria Sporozoite Surface Is Essential for Gliding Motility and Sporozoite Infectivity

  • Ijeoma Ejigiri,

    Affiliation: Department of Microbiology, New York University School of Medicine, New York, New York, United States of America

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  • Daniel R. T. Ragheb,

    Affiliation: Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Paco Pino,

    Affiliation: Department of Microbiology, School of Medicine, University of Geneva, Geneva, Switzerland

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  • Alida Coppi,

    Affiliation: Department of Microbiology, New York University School of Medicine, New York, New York, United States of America

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  • Brandy Lee Bennett,

    Affiliation: Department of Microbiology, New York University School of Medicine, New York, New York, United States of America

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  • Dominique Soldati-Favre,

    Affiliation: Department of Microbiology, School of Medicine, University of Geneva, Geneva, Switzerland

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  • Photini Sinnis mail

    psinnis@jhsph.edu

    Affiliations: Department of Microbiology, New York University School of Medicine, New York, New York, United States of America, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    Current address: Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.ppat.1002725

About the Authors

Ijeoma Ejigiri, Alida Coppi, Brandy Lee Bennett, Photini Sinnis
Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
Daniel R. T. Ragheb, Photini Sinnis
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Paco Pino, Dominique Soldati-Favre
Department of Microbiology, School of Medicine, University of Geneva, Geneva, Switzerland

Corresponding Author

Email: psinnis@jhsph.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PS IE DSF. Performed the experiments: IE DRTR AC PP BLB. Analyzed the data: IE PS DRTR PP DSF. Contributed reagents/materials/analysis tools: IE PS PP DSF. Wrote the paper: IE PS.