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Research Article

Evolution of Salmonella enterica Virulence via Point Mutations in the Fimbrial Adhesin

  • Dagmara I. Kisiela,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Sujay Chattopadhyay,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Stephen J. Libby,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Joyce E. Karlinsey,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Ferric C. Fang,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Veronika Tchesnokova,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Jeremy J. Kramer,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Viktoriya Beskhlebnaya,

    Affiliation: Institute for Environmental Health, Lake Forest Park, Washington, United States of America

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  • Mansour Samadpour,

    Affiliation: Institute for Environmental Health, Lake Forest Park, Washington, United States of America

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  • Krzysztof Grzymajlo,

    Affiliation: Department of Biochemistry, Pharmacology and Toxicology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland

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  • Maciej Ugorski,

    Affiliation: Department of Biochemistry, Pharmacology and Toxicology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland

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  • Emily W. Lankau,

    Affiliation: Department of Animal Sciences, University of Illinois, Urbana, Illinois, United States of America

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  • Roderick I. Mackie,

    Affiliation: Department of Animal Sciences, University of Illinois, Urbana, Illinois, United States of America

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  • Steven Clegg,

    Affiliation: Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America

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  • Evgeni V. Sokurenko mail

    evs@u.washington.edu

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Published: June 07, 2012
  • DOI: 10.1371/journal.ppat.1002733

About the Authors

Dagmara I. Kisiela, Sujay Chattopadhyay, Stephen J. Libby, Joyce E. Karlinsey, Ferric C. Fang, Veronika Tchesnokova, Jeremy J. Kramer, Evgeni V. Sokurenko
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
Viktoriya Beskhlebnaya, Mansour Samadpour
Institute for Environmental Health, Lake Forest Park, Washington, United States of America
Krzysztof Grzymajlo, Maciej Ugorski
Department of Biochemistry, Pharmacology and Toxicology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
Emily W. Lankau, Roderick I. Mackie
Department of Animal Sciences, University of Illinois, Urbana, Illinois, United States of America
Steven Clegg
Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America

Corresponding Author

Email: evs@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: D. Kisiela, S. Libby, V. Tchesnokova, E. Sokurenko. Performed the experiments: D. Kisiela, S. Chattopadhyay, J. Kramer, S. Libby, K. Grzymajlo, E. Lankau, J. Karlinsey, V. Beskhlebnaya. Analyzed the data: D. Kisiela, S. Chattopadhyay, S. Libby, M. Ugorski, R. Mackie, S. Clegg, F. Fang, M. Samadpour, E. Sokurenko. Contributed reagents/materials/analysis tools: M. Ugorski, R. Mackie, S. Clegg, S. Libby, F. Fang, M. Samadpour. Wrote the paper: D. Kisiela, S. Chattopadhyay, E. Sokurenko.