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Research Article

HIV-Specific Antibodies Capable of ADCC Are Common in Breastmilk and Are Associated with Reduced Risk of Transmission in Women with High Viral Loads

  • Jennifer Mabuka,

    Affiliations: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Program of Pathobiology, Department of Global Health, University of Washington, Seattle, Washington, United States of America

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  • Ruth Nduati,

    Affiliation: Department of Pediatrics, University of Nairobi, Nairobi, Kenya

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  • Katherine Odem-Davis,

    Affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Dylan Peterson,

    Affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Julie Overbaugh mail

    joverbau@fhcrc.org

    Affiliations: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Published: June 14, 2012
  • DOI: 10.1371/journal.ppat.1002739

About the Authors

Jennifer Mabuka, Katherine Odem-Davis, Dylan Peterson, Julie Overbaugh
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Jennifer Mabuka
Program of Pathobiology, Department of Global Health, University of Washington, Seattle, Washington, United States of America
Ruth Nduati
Department of Pediatrics, University of Nairobi, Nairobi, Kenya
Julie Overbaugh
Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Corresponding Author

Email: joverbau@fhcrc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JM RN JO. Performed the experiments: JM DP. Analyzed the data: JM KOD. Contributed reagents/materials/analysis tools: RN KOD JO. Wrote the paper: JM JO. Provided comments on the manuscript: RN KOD DP Provided overall guidance: JO.