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Research Article

Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB

  • Hua Xiang equal contributor,

    equal contributor Contributed equally to this work with: Hua Xiang, Yue Feng

    Affiliations: Key Laboratory for Protein Sciences of Ministry of Education, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China, Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, China

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  • Yue Feng equal contributor,

    equal contributor Contributed equally to this work with: Hua Xiang, Yue Feng

    Affiliation: Key Laboratory for Protein Sciences of Ministry of Education, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

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  • Jiawei Wang,

    Affiliation: Key Laboratory for Protein Sciences of Ministry of Education, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

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  • Bao Liu,

    Affiliation: Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing, China

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  • Yeguang Chen,

    Affiliation: Key Laboratory for Protein Sciences of Ministry of Education, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

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  • Lei Liu,

    Affiliations: Key Laboratory for Protein Sciences of Ministry of Education, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China, Department of Chemistry, Tsinghua University, Beijing, China

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  • Xuming Deng mail,

    xumingdeng@jluhp.edu.cn (XD); maojunyang@tsinghua.edu.cn (MY)

    Affiliation: Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, China

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  • Maojun Yang mail

    xumingdeng@jluhp.edu.cn (XD); maojunyang@tsinghua.edu.cn (MY)

    Affiliation: Key Laboratory for Protein Sciences of Ministry of Education, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

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  • Published: June 14, 2012
  • DOI: 10.1371/journal.ppat.1002751

About the Authors

Hua Xiang, Yue Feng, Jiawei Wang, Yeguang Chen, Lei Liu, Maojun Yang
Key Laboratory for Protein Sciences of Ministry of Education, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
Hua Xiang, Xuming Deng
Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, China
Bao Liu
Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing, China
Lei Liu
Department of Chemistry, Tsinghua University, Beijing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MY. Performed the experiments: HX YF JW BL LL. Analyzed the data: MY HX YF JW BL LL YC XD. Contributed reagents/materials/analysis tools: BL LL YC. Wrote the paper: MY.