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Research Article

The Interdomain Linker of AAV-2 Rep68 Is an Integral Part of Its Oligomerization Domain: Role of a Conserved SF3 Helicase Residue in Oligomerization

  • Francisco Zarate-Perez,

    Affiliation: Department of Physiology and Biophysics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, United States of America

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  • Martino Bardelli,

    Affiliation: Department of Infectious Diseases, King's College London School of Medicine at Guy's, King's and St. Thomas Hospital, London, United Kingdom

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  • John W. Burgner II,

    Affiliation: Department of Physiology and Biophysics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, United States of America

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  • Maria Villamil-Jarauta,

    Affiliation: Department of Physiology and Biophysics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, United States of America

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  • Kanni Das,

    Affiliation: Department of Physiology and Biophysics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, United States of America

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  • Demet Kekilli,

    Affiliation: Department of Applied Sciences, University of the West of England, Bristol, United Kingdom

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  • Jorge Mansilla-Soto,

    Affiliation: Center for Cell Engineering, Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • R. Michael Linden mail,

    cescalante@vcu.edu (CRE); michael.linden@kcl.ac.uk (ML)

    Affiliations: Department of Infectious Diseases, King's College London School of Medicine at Guy's, King's and St. Thomas Hospital, London, United Kingdom, UCL Gene Therapy Consortium, UCL Cancer Institute, University College London, London, United Kingdom

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  • Carlos R. Escalante mail

    cescalante@vcu.edu (CRE); michael.linden@kcl.ac.uk (ML)

    Affiliation: Department of Physiology and Biophysics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, United States of America

    X
  • Published: June 14, 2012
  • DOI: 10.1371/journal.ppat.1002764

About the Authors

Francisco Zarate-Perez, John W. Burgner II, Maria Villamil-Jarauta, Kanni Das, Carlos R. Escalante
Department of Physiology and Biophysics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia, United States of America
Martino Bardelli, R. Michael Linden
Department of Infectious Diseases, King's College London School of Medicine at Guy's, King's and St. Thomas Hospital, London, United Kingdom
Demet Kekilli
Department of Applied Sciences, University of the West of England, Bristol, United Kingdom
Jorge Mansilla-Soto
Center for Cell Engineering, Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
R. Michael Linden
UCL Gene Therapy Consortium, UCL Cancer Institute, University College London, London, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FZP CRE RML JMS. Performed the experiments: FZP MB CRE JWB MVJ KD DK. Analyzed the data: FZP MB JWB CRE. Wrote the paper: FZP MB RML CRE.