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Research Article

Opposing Regulation of PROX1 by Interleukin-3 Receptor and NOTCH Directs Differential Host Cell Fate Reprogramming by Kaposi Sarcoma Herpes Virus

  • Jaehyuk Yoo equal contributor,

    equal contributor Contributed equally to this work with: Jaehyuk Yoo, Ha Neul Lee

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Ha Neul Lee equal contributor,

    equal contributor Contributed equally to this work with: Jaehyuk Yoo, Ha Neul Lee

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Inho Choi,

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

    X
  • Dongwon Choi,

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

    X
  • Hee Kyoung Chung,

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Kyu Eui Kim,

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Sunju Lee,

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

    X
  • Berenice Aguilar,

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Jinjoo Kang,

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Eunkyung Park,

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Yong Suk Lee,

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Yong-Sun Maeng,

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Nam Yoon Kim,

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Chester J. Koh,

    Affiliation: Division of Pediatric Urology, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

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  • Young-Kwon Hong mail

    young.hong@usc.edu

    Affiliation: Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

    X
  • Published: June 14, 2012
  • DOI: 10.1371/journal.ppat.1002770

About the Authors

Jaehyuk Yoo, Ha Neul Lee, Inho Choi, Dongwon Choi, Hee Kyoung Chung, Kyu Eui Kim, Sunju Lee, Berenice Aguilar, Jinjoo Kang, Eunkyung Park, Yong Suk Lee, Yong-Sun Maeng, Nam Yoon Kim, Young-Kwon Hong
Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Chester J. Koh
Division of Pediatric Urology, Children's Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, United States of America

Corresponding Author

Email: young.hong@usc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JY HNL IC DC HKC KEK SL BA JK EP YSL YSM NYK YKH. Performed the experiments: JY HNL IC DC HKC KEK SL BA JK EP YSL YSM NYK. Analyzed the data: JY HNL IC DC YKH. Contributed reagents/materials/analysis tools: CJK. Wrote the paper: YKH.