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Research Article

A Highly Intensified ART Regimen Induces Long-Term Viral Suppression and Restriction of the Viral Reservoir in a Simian AIDS Model

  • Iart Luca Shytaj equal contributor,

    equal contributor Contributed equally to this work with: Iart Luca Shytaj, Sandro Norelli, Barbara Chirullo

    Affiliation: Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, Rome, Italy

    X
  • Sandro Norelli equal contributor,

    equal contributor Contributed equally to this work with: Iart Luca Shytaj, Sandro Norelli, Barbara Chirullo

    Affiliation: Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, Rome, Italy

    X
  • Barbara Chirullo equal contributor,

    equal contributor Contributed equally to this work with: Iart Luca Shytaj, Sandro Norelli, Barbara Chirullo

    Affiliation: Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, Rome, Italy

    X
  • Alessandro Della Corte,

    Affiliation: Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, Rome, Italy

    X
  • Matt Collins,

    Affiliation: BIOQUAL, Inc., Rockville, Maryland, United States of America

    X
  • Jake Yalley-Ogunro,

    Affiliation: BIOQUAL, Inc., Rockville, Maryland, United States of America

    X
  • Jack Greenhouse,

    Affiliation: BIOQUAL, Inc., Rockville, Maryland, United States of America

    X
  • Nunzio Iraci,

    Affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Facoltà di Farmacia, Università di Perugia, Perugia, Italy

    X
  • Edward P. Acosta,

    Affiliation: The University of Alabama at Birmingham, Division of Clinical Pharmacology, Birmingham, Alabama, United States of America

    X
  • Maria Letizia Barreca,

    Affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Facoltà di Farmacia, Università di Perugia, Perugia, Italy

    X
  • Mark G. Lewis,

    Affiliation: BIOQUAL, Inc., Rockville, Maryland, United States of America

    X
  • Andrea Savarino mail

    andrea.savarino@iss.it

    Affiliation: Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, Rome, Italy

    X
  • Published: June 21, 2012
  • DOI: 10.1371/journal.ppat.1002774

About the Authors

Iart Luca Shytaj, Sandro Norelli, Barbara Chirullo, Alessandro Della Corte, Andrea Savarino
Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, Rome, Italy
Matt Collins, Jake Yalley-Ogunro, Jack Greenhouse, Mark G. Lewis
BIOQUAL, Inc., Rockville, Maryland, United States of America
Nunzio Iraci, Maria Letizia Barreca
Dipartimento di Chimica e Tecnologia del Farmaco, Facoltà di Farmacia, Università di Perugia, Perugia, Italy
Edward P. Acosta
The University of Alabama at Birmingham, Division of Clinical Pharmacology, Birmingham, Alabama, United States of America

Corresponding Author

Email: andrea.savarino@iss.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS MGL MLB ILS. Performed the experiments: ILS SN BC JJO JG MC NI EPA ADC. Analyzed the data: AS ILS NI ADC. Contributed reagents/materials/analysis tools: AS EPA MGL. Wrote the paper: AS ILS.