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Research Article

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

  • Wendy Niedelman,

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Daniel A. Gold,

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Emily E. Rosowski,

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Joris K. Sprokholt,

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Cell Biology and Immunology, Wageningen University and Research Centre, Wageningen, The Netherlands

    X
  • Daniel Lim,

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Ailan Farid Arenas,

    Affiliation: Group of Molecular Parasitology, Universidad del Quindio, Quindio, Colombia

    X
  • Mariane B. Melo,

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Eric Spooner,

    Affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

    X
  • Michael B. Yaffe,

    Affiliations: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Jeroen P. J. Saeij mail

    jsaeij@mit.edu

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Published: June 28, 2012
  • DOI: 10.1371/journal.ppat.1002784

About the Authors

Wendy Niedelman, Daniel A. Gold, Emily E. Rosowski, Joris K. Sprokholt, Daniel Lim, Mariane B. Melo, Michael B. Yaffe, Jeroen P. J. Saeij
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Joris K. Sprokholt
Department of Cell Biology and Immunology, Wageningen University and Research Centre, Wageningen, The Netherlands
Daniel Lim, Michael B. Yaffe
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Ailan Farid Arenas
Group of Molecular Parasitology, Universidad del Quindio, Quindio, Colombia
Eric Spooner
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: jsaeij@mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WN JS DAG JPJS. Performed the experiments: WN JS EER DAG AF MBM DL ES. Analyzed the data: WN JS MBM DAG JPJS. Contributed reagents/materials/analysis tools: DL ES MBY. Wrote the paper: WN JS DAG JPJS.