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Research Article

Pathogenicity and Transmissibility of North American Triple Reassortant Swine Influenza A Viruses in Ferrets

  • Subrata Barman,

    Affiliation: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Petr S. Krylov,

    Affiliation: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Thomas P. Fabrizio,

    Affiliation: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • John Franks,

    Affiliation: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Jasmine C. Turner,

    Affiliation: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Patrick Seiler,

    Affiliation: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • David Wang,

    Affiliation: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Jerold E. Rehg,

    Affiliation: Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Gene A. Erickson,

    Affiliation: Veterinary Diagnostic Laboratory (NCVDL) System, North Carolina Department of Agriculture, Raleigh, North Carolina, United States of America

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  • Marie Gramer,

    Affiliation: Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America

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  • Robert G. Webster,

    Affiliation: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Richard J. Webby mail

    Richard.webby@stjude.org

    Affiliation: Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Published: July 19, 2012
  • DOI: 10.1371/journal.ppat.1002791

About the Authors

Subrata Barman, Petr S. Krylov, Thomas P. Fabrizio, John Franks, Jasmine C. Turner, Patrick Seiler, David Wang, Robert G. Webster, Richard J. Webby
Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Jerold E. Rehg
Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Gene A. Erickson
Veterinary Diagnostic Laboratory (NCVDL) System, North Carolina Department of Agriculture, Raleigh, North Carolina, United States of America
Marie Gramer
Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, United States of America

Corresponding Author

Email: Richard.webby@stjude.org

Competing Interests

Dr. Webster receives funding from F. Hoffmann LaRoche Ltd., but the funds were not used in support of the research presented in the manuscript. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SB RGW RJW. Performed the experiments: SB PSK TPF JF JCT PS DW JER. Analyzed the data: SB RGW RJW JER. Contributed reagents/materials/analysis tools: JER. Wrote the paper: SB RGW RJW GAE MG. Conducted experiments with ferrets: SB PSK TPF JF JCT PS DW. Sequenced the TRS viruses: SB PSK TPF. Isolation and initial characterization of the TRS viruses: GAE MG. Ferret lung pathology and data analysis: JER.