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Research Article

Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation

  • Erin E. H. Tran equal contributor,

    equal contributor Contributed equally to this work with: Erin E. H. Tran, Mario J. Borgnia

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

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  • Mario J. Borgnia equal contributor,

    equal contributor Contributed equally to this work with: Erin E. H. Tran, Mario J. Borgnia

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

    X
  • Oleg Kuybeda,

    Affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

    Current address: National Library of Medicine, NIH, Bethesda, Maryland, United States of America

    X
  • David M. Schauder,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

    X
  • Alberto Bartesaghi,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

    X
  • Gabriel A. Frank,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

    X
  • Guillermo Sapiro,

    Affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Jacqueline L. S. Milne,

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

    X
  • Sriram Subramaniam mail

    ss1@nih.gov

    Affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America

    X
  • Published: July 12, 2012
  • DOI: 10.1371/journal.ppat.1002797

About the Authors

Erin E. H. Tran, Mario J. Borgnia, David M. Schauder, Alberto Bartesaghi, Gabriel A. Frank, Jacqueline L. S. Milne, Sriram Subramaniam
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America
Oleg Kuybeda, Guillermo Sapiro
Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

Corresponding Author

Email: ss1@nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EEHT MJB OK SS. Performed the experiments: EEHT MJB DMS SS. Analyzed the data: EEHT MJB OK SS. Contributed reagents/materials/analysis tools: GAF AB GS. Wrote the paper: EEHT JLSM SS.