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Research Article

Evidence for Antigenic Seniority in Influenza A (H3N2) Antibody Responses in Southern China

  • Justin Lessler,

    Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    X
  • Steven Riley mail,

    s.riley@imperial.ac.uk

    Affiliation: School of Public Health, Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modelling, Imperial College, London, United Kingdom

    X
  • Jonathan M. Read,

    Affiliation: Department of Epidemiology and Population Health, Institute of Infection and Global Health, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom

    X
  • Shuying Wang,

    Affiliation: Guangzhou No. 12 Hospital, Guangzhou, Guangdong, China

    X
  • Huachen Zhu,

    Affiliations: International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China

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  • Gavin J. D. Smith,

    Affiliation: Laboratory of Virus Evolution, Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore, Singapore

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  • Yi Guan,

    Affiliations: International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China

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  • Chao Qiang Jiang,

    Affiliation: Guangzhou No. 12 Hospital, Guangzhou, Guangdong, China

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  • Derek A. T. Cummings

    Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Published: July 19, 2012
  • DOI: 10.1371/journal.ppat.1002802

About the Authors

Justin Lessler, Derek A. T. Cummings
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Steven Riley
School of Public Health, Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modelling, Imperial College, London, United Kingdom
Jonathan M. Read
Department of Epidemiology and Population Health, Institute of Infection and Global Health, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom
Shuying Wang, Chao Qiang Jiang
Guangzhou No. 12 Hospital, Guangzhou, Guangdong, China
Huachen Zhu, Yi Guan
International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China
Huachen Zhu, Yi Guan
Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China
Gavin J. D. Smith
Laboratory of Virus Evolution, Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore, Singapore

Corresponding Author

Email: s.riley@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SR DATC JMR GJDS CQJ YG. Performed the experiments: SW HZ. Analyzed the data: SR DATC JMR. Wrote the paper: JL SR JMR DATC.