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Research Article

Type I Interferons Promote Fatal Immunopathology by Regulating Inflammatory Monocytes and Neutrophils during Candida Infections

  • Olivia Majer,

    Affiliation: Medical University Vienna - Max F. Perutz Laboratories, Christian Doppler Laboratory for Infection Biology, Campus Vienna Biocenter, Vienna, Austria

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  • Christelle Bourgeois,

    Affiliation: Medical University Vienna - Max F. Perutz Laboratories, Christian Doppler Laboratory for Infection Biology, Campus Vienna Biocenter, Vienna, Austria

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  • Florian Zwolanek,

    Affiliation: Medical University Vienna - Max F. Perutz Laboratories, Christian Doppler Laboratory for Infection Biology, Campus Vienna Biocenter, Vienna, Austria

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  • Caroline Lassnig,

    Affiliation: University of Veterinary Medicine Vienna, Institute of Animal Breeding and Genetics & Biomodels Austria, Vienna, Austria

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  • Dontscho Kerjaschki,

    Affiliation: Medical University of Vienna – Clinical Institute of Pathology, AKH - General Hospital of Vienna, Vienna, Austria

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  • Matthias Mack,

    Affiliation: University Hospital of Regensburg, Internal Medicine II – Nephrology, Regensburg, Germany

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  • Mathias Müller,

    Affiliation: University of Veterinary Medicine Vienna, Institute of Animal Breeding and Genetics & Biomodels Austria, Vienna, Austria

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  • Karl Kuchler mail

    karl.kuchler@meduniwien.ac.at

    Affiliation: Medical University Vienna - Max F. Perutz Laboratories, Christian Doppler Laboratory for Infection Biology, Campus Vienna Biocenter, Vienna, Austria

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.ppat.1002811

About the Authors

Olivia Majer, Christelle Bourgeois, Florian Zwolanek, Karl Kuchler
Medical University Vienna - Max F. Perutz Laboratories, Christian Doppler Laboratory for Infection Biology, Campus Vienna Biocenter, Vienna, Austria
Caroline Lassnig, Mathias Müller
University of Veterinary Medicine Vienna, Institute of Animal Breeding and Genetics & Biomodels Austria, Vienna, Austria
Dontscho Kerjaschki
Medical University of Vienna – Clinical Institute of Pathology, AKH - General Hospital of Vienna, Vienna, Austria
Matthias Mack
University Hospital of Regensburg, Internal Medicine II – Nephrology, Regensburg, Germany

Corresponding Author

Email: karl.kuchler@meduniwien.ac.at

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: O. Majer, K. Kuchler. Performed the experiments: O. Majer, C. Bourgeois, F. Zwolanek, C. Lassnig, D. Kerjaschki. Analyzed the data: O. Majer. Contributed reagents/materials/analysis tools: M. Mack, M. Müller. Wrote the paper: O. Majer, K. Kuchler.