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Research Article

The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity

  • Magali Bebien,

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Mary E. Hensler,

    Affiliation: Department of Pediatrics and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, School of Medicine, La Jolla, California, United States of America

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  • Suzel Davanture,

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Li-Chung Hsu,

    Affiliation: Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla, California, United States of America

    Current address: Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

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  • Michael Karin,

    Affiliation: Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla, California, United States of America

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  • Jin Mo Park,

    Affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

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  • Lena Alexopoulou,

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • George Y. Liu,

    Affiliation: Immunobiology Institute, Cedars-Sinai Medical Center, University of California Los Angeles, School of Medicine, Los Angeles, California, United States of America

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  • Victor Nizet,

    Affiliation: Department of Pediatrics and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, School of Medicine, La Jolla, California, United States of America

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  • Toby Lawrence mail

    lawrence@ciml.univ-mrs.fr

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Published: July 19, 2012
  • DOI: 10.1371/journal.ppat.1002812

About the Authors

Magali Bebien, Suzel Davanture, Lena Alexopoulou, Toby Lawrence
Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France
Magali Bebien, Suzel Davanture, Lena Alexopoulou, Toby Lawrence
Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France
Magali Bebien, Suzel Davanture, Lena Alexopoulou, Toby Lawrence
Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France
Mary E. Hensler, Victor Nizet
Department of Pediatrics and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, School of Medicine, La Jolla, California, United States of America
Li-Chung Hsu, Michael Karin
Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla, California, United States of America
Jin Mo Park
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
George Y. Liu
Immunobiology Institute, Cedars-Sinai Medical Center, University of California Los Angeles, School of Medicine, Los Angeles, California, United States of America

Corresponding Author

Email: lawrence@ciml.univ-mrs.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TL MB. Performed the experiments: TL MB SD. Analyzed the data: TL MB. Contributed reagents/materials/analysis tools: LA JMP GYL MK VN LCH MEH. Wrote the paper: TL MB.