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Research Article

Monocytes Regulate the Mechanism of T-cell Death by Inducing Fas-Mediated Apoptosis during Bacterial Infection

  • Marc Daigneault,

    Affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom

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  • Thushan I. De Silva,

    Affiliations: Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom, Sheffield Teaching Hospitals, Sheffield, United Kingdom

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  • Martin A. Bewley,

    Affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom

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  • Julie A. Preston,

    Affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom

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  • Helen M. Marriott,

    Affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom

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  • Andrea M. Mitchell,

    Affiliation: Institute of Microbiology and Infection, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom

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  • Timothy J. Mitchell,

    Affiliation: Institute of Microbiology and Infection, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom

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  • Robert C. Read,

    Affiliations: Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom, Sheffield Teaching Hospitals, Sheffield, United Kingdom

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  • Moira K. B. Whyte,

    Affiliations: Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom, Sheffield Teaching Hospitals, Sheffield, United Kingdom

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  • David H. Dockrell mail

    d.h.dockrell@sheffield.ac.uk

    Affiliations: Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom, Sheffield Teaching Hospitals, Sheffield, United Kingdom

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  • Published: July 19, 2012
  • DOI: 10.1371/journal.ppat.1002814

About the Authors

Marc Daigneault, Thushan I. De Silva, Martin A. Bewley, Julie A. Preston, Helen M. Marriott, Robert C. Read, Moira K. B. Whyte, David H. Dockrell
Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom
Thushan I. De Silva, Robert C. Read, Moira K. B. Whyte, David H. Dockrell
Sheffield Teaching Hospitals, Sheffield, United Kingdom
Andrea M. Mitchell, Timothy J. Mitchell
Institute of Microbiology and Infection, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom

Corresponding Author

Email: d.h.dockrell@sheffield.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DHD. Performed the experiments: MD TID MAB AMM JAP HMM. Analyzed the data: MD MAB JAP HMM. Contributed reagents/materials/analysis tools: AMM TJM RCR. Wrote the paper: MD DHD MKBW.