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Research Article

Opposing Roles for Interferon Regulatory Factor-3 (IRF-3) and Type I Interferon Signaling during Plague

  • Ami A. Patel,

    Affiliations: Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, United States of America, Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri, United States of America

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  • Hanni Lee-Lewis,

    Affiliations: Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, United States of America, Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri, United States of America

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  • Jennifer Hughes-Hanks equal contributor,

    equal contributor Contributed equally to this work with: Jennifer Hughes-Hanks, Craig A. Lewis

    Affiliation: Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, United States of America

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  • Craig A. Lewis equal contributor,

    equal contributor Contributed equally to this work with: Jennifer Hughes-Hanks, Craig A. Lewis

    Affiliation: Starling Enterprise, LLC, Columbia, Missouri, United States of America

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  • Deborah M. Anderson mail

    andersondeb@missouri.edu

    Affiliations: Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, United States of America, Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri, United States of America

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.ppat.1002817

About the Authors

Ami A. Patel, Hanni Lee-Lewis, Jennifer Hughes-Hanks, Deborah M. Anderson
Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, United States of America
Ami A. Patel, Hanni Lee-Lewis, Deborah M. Anderson
Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri, United States of America
Craig A. Lewis
Starling Enterprise, LLC, Columbia, Missouri, United States of America

Corresponding Author

Email: andersondeb@missouri.edu

Competing Interests

Starling Enterprises offers statistical analysis of biological data as well as consulting on study design and analysis. Dr. Lewis is the chief officer of this company and there are no associated commercial products. Dr. Lewis was provided with all raw data collected for survival, titer, cytokine and real time PCR experiments shown in the paper and he returned appropriate statistical analyses on these data. There was no competing financial interest with Starling Enterprise. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AAP DMA. Performed the experiments: AAP. Analyzed the data: AAP JHH HLL CAL DMA. Wrote the paper: AAP DMA.