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Research Article

Directly Infected Resting CD4+T Cells Can Produce HIV Gag without Spreading Infection in a Model of HIV Latency

  • Matthew J. Pace,

    Affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Erin H. Graf,

    Affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Luis M. Agosto,

    Affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Angela M. Mexas,

    Affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Frances Male,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Troy Brady,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Frederic D. Bushman,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Una O'Doherty mail

    unao@mail.med.upenn.edu

    Affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.ppat.1002818

About the Authors

Matthew J. Pace, Erin H. Graf, Luis M. Agosto, Angela M. Mexas, Una O'Doherty
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Frances Male, Troy Brady, Frederic D. Bushman
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: unao@mail.med.upenn.edu

Competing Interests

This work was funded in part by a grant from Merck. There are no other connections (patents, consultation, products in development etc). This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MJP LMA EHG AMM TB FDB UO. Performed the experiments: MJP LMA EHG FM TB. Analyzed the data: MJP LMA TB FDB UO. Contributed reagents/materials/analysis tools: TB FDB. Wrote the paper: MJP LMA EHG AMM TB FDB UO.