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Research Article

Germline Transgenesis and Insertional Mutagenesis in Schistosoma mansoni Mediated by Murine Leukemia Virus

  • Gabriel Rinaldi equal contributor,

    equal contributor Contributed equally to this work with: Gabriel Rinaldi, Sabine E. Eckert, Isheng J. Tsai

    Affiliations: Department of Microbiology, Immunology & Tropical Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC, United States of America, Departamento de Genética, Facultad de Medicina, Universidad de la República, (UDELAR), Montevideo, Uruguay

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  • Sabine E. Eckert equal contributor,

    equal contributor Contributed equally to this work with: Gabriel Rinaldi, Sabine E. Eckert, Isheng J. Tsai

    Affiliations: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, Oxford Nanopore Technologies, Oxford, United Kingdom

    X
  • Isheng J. Tsai equal contributor,

    equal contributor Contributed equally to this work with: Gabriel Rinaldi, Sabine E. Eckert, Isheng J. Tsai

    Affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Sutas Suttiprapa,

    Affiliations: Department of Microbiology, Immunology & Tropical Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC, United States of America, Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand

    X
  • Kristine J. Kines,

    Affiliations: Department of Microbiology, Immunology & Tropical Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC, United States of America, Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America

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  • José F. Tort,

    Affiliation: Departamento de Genética, Facultad de Medicina, Universidad de la República, (UDELAR), Montevideo, Uruguay

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  • Victoria H. Mann,

    Affiliation: Department of Microbiology, Immunology & Tropical Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC, United States of America

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  • Daniel J. Turner,

    Affiliations: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, Oxford Nanopore Technologies, Oxford, United Kingdom

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  • Matthew Berriman mail,

    mb4@sanger.ac.uk (MB); pbrindley@gwu.edu (PJB)

    Affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Paul J. Brindley mail

    mb4@sanger.ac.uk (MB); pbrindley@gwu.edu (PJB)

    Affiliations: Department of Microbiology, Immunology & Tropical Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC, United States of America, Research Center for Neglected Diseases of Poverty, The George Washington University, Washington, DC, United States of America

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.ppat.1002820

About the Authors

Gabriel Rinaldi, Sutas Suttiprapa, Kristine J. Kines, Victoria H. Mann, Paul J. Brindley
Department of Microbiology, Immunology & Tropical Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC, United States of America
Gabriel Rinaldi, José F. Tort
Departamento de Genética, Facultad de Medicina, Universidad de la República, (UDELAR), Montevideo, Uruguay
Sabine E. Eckert, Isheng J. Tsai, Daniel J. Turner, Matthew Berriman
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
Sabine E. Eckert, Daniel J. Turner
Oxford Nanopore Technologies, Oxford, United Kingdom
Sutas Suttiprapa
Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand
Kristine J. Kines
Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America
Paul J. Brindley
Research Center for Neglected Diseases of Poverty, The George Washington University, Washington, DC, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GR SEE IJT DJT MB PJB. Performed the experiments: GR SEE IJT KJK SS VHM. Analyzed the data: GR SEE IJT JFT MB PJB. Contributed reagents/materials/analysis tools: KJK VHM DJT IJT. Wrote the paper: GR SEE IJT JFT MB PJB.