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Research Article

Identification of Site-Specific Adaptations Conferring Increased Neural Cell Tropism during Human Enterovirus 71 Infection

  • Samuel Cordey equal contributor mail,

    equal contributor Contributed equally to this work with: Samuel Cordey, Tom J. Petty

    samuel.cordey@hcuge.ch

    Affiliations: Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva, Geneva, Switzerland, Department of Medicine, University of Geneva Medical School, Geneva, Switzerland

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  • Tom J. Petty equal contributor,

    equal contributor Contributed equally to this work with: Samuel Cordey, Tom J. Petty

    Affiliations: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland, Swiss Institute of Bioinformatics, Geneva, Switzerland

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  • Manuel Schibler,

    Affiliations: Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva, Geneva, Switzerland, Department of Medicine, University of Geneva Medical School, Geneva, Switzerland

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  • Yannick Martinez,

    Affiliation: Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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  • Daniel Gerlach,

    Affiliation: Research Institute of Molecular Pathology (IMP), Vienna, Austria

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  • Sandra van Belle,

    Affiliations: Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva, Geneva, Switzerland, Department of Medicine, University of Geneva Medical School, Geneva, Switzerland

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  • Lara Turin,

    Affiliations: Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva, Geneva, Switzerland, Department of Medicine, University of Geneva Medical School, Geneva, Switzerland

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  • Evgeny Zdobnov,

    Affiliations: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland, Swiss Institute of Bioinformatics, Geneva, Switzerland, Imperial College London, South Kensington Campus, London, United Kingdom

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  • Laurent Kaiser ,

    Affiliations: Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva, Geneva, Switzerland, Department of Medicine, University of Geneva Medical School, Geneva, Switzerland

    These authors also contributed equally to this work.

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  • Caroline Tapparel

    Affiliations: Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva, Geneva, Switzerland, Department of Medicine, University of Geneva Medical School, Geneva, Switzerland

    These authors also contributed equally to this work.

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.ppat.1002826

About the Authors

Samuel Cordey, Manuel Schibler, Sandra van Belle, Lara Turin, Laurent Kaiser, Caroline Tapparel
Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva, Geneva, Switzerland
Samuel Cordey, Manuel Schibler, Sandra van Belle, Lara Turin, Laurent Kaiser, Caroline Tapparel
Department of Medicine, University of Geneva Medical School, Geneva, Switzerland
Tom J. Petty, Evgeny Zdobnov
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
Tom J. Petty, Evgeny Zdobnov
Swiss Institute of Bioinformatics, Geneva, Switzerland
Yannick Martinez
Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Daniel Gerlach
Research Institute of Molecular Pathology (IMP), Vienna, Austria
Evgeny Zdobnov
Imperial College London, South Kensington Campus, London, United Kingdom

Corresponding Author

Email: samuel.cordey@hcuge.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SC TJP LK CT. Performed the experiments: MS SC YM SVB LT. Analyzed the data: SC TJP DG LK CT. Wrote the paper: SC TJP DG EZ LK CT.