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Research Article

IL-10-Producing Th1 Cells and Disease Progression Are Regulated by Distinct CD11c+ Cell Populations during Visceral Leishmaniasis

  • Benjamin M. J. Owens,
  • Lynette Beattie,

    Affiliation: Centre for Immunology & Infection, Hull York Medical School and Department of Biology, University of York, York, United Kingdom

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  • John W. J. Moore,

    Affiliation: Centre for Immunology & Infection, Hull York Medical School and Department of Biology, University of York, York, United Kingdom

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  • Najmeeyah Brown,

    Affiliation: Centre for Immunology & Infection, Hull York Medical School and Department of Biology, University of York, York, United Kingdom

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  • Jason L. Mann,

    Affiliation: Centre for Immunology & Infection, Hull York Medical School and Department of Biology, University of York, York, United Kingdom

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  • Jane E. Dalton,

    Affiliation: Centre for Immunology & Infection, Hull York Medical School and Department of Biology, University of York, York, United Kingdom

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  • Asher Maroof,

    Affiliation: Centre for Immunology & Infection, Hull York Medical School and Department of Biology, University of York, York, United Kingdom

    Current address: UCB Pharma, Slough, Berkshire, United Kingdom

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  • Paul M. Kaye mail

    paul.kaye@york.ac.uk

    Affiliation: Centre for Immunology & Infection, Hull York Medical School and Department of Biology, University of York, York, United Kingdom

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.ppat.1002827

About the Authors

Lynette Beattie, John W. J. Moore, Najmeeyah Brown, Jason L. Mann, Jane E. Dalton, Asher Maroof, Paul M. Kaye
Centre for Immunology & Infection, Hull York Medical School and Department of Biology, University of York, York, United Kingdom

Corresponding Author

Email: paul.kaye@york.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BMJO LB AM PMK. Performed the experiments: BMJO LB AM NB JWJM JLM JED. Analyzed the data: BMJO PMK. Wrote the paper: BMJO PMK. Supervised the study: PMK.