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Research Article

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

  • Rebecca M. DuBois,

    Affiliations: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • P. Jake Slavish,

    Affiliation: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Brandi M. Baughman,

    Affiliations: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Mi-Kyung Yun,

    Affiliation: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Ju Bao,

    Affiliation: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Richard J. Webby,

    Affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Thomas R. Webb,

    Affiliations: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Stephen W. White mail

    Stephen.White@stjude.org

    Affiliations: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.ppat.1002830

About the Authors

Rebecca M. DuBois, Mi-Kyung Yun, Ju Bao, Stephen W. White
Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Rebecca M. DuBois, Richard J. Webby
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
P. Jake Slavish, Brandi M. Baughman, Thomas R. Webb
Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Brandi M. Baughman, Thomas R. Webb, Stephen W. White
Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

Corresponding Author

Email: Stephen.White@stjude.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RMD PJS SWW. Performed the experiments: RMD PJS BMB MY. Analyzed the data: RMD PJS JB RJW TRW SWW. Contributed reagents/materials/analysis tools: JB. Wrote the paper: RMD SWW.